Gene‐by‐age effects on BMI from birth to adulthood: The fels longitudinal study

Objectives Genome wide association studies have shown 32 loci to influence BMI in European‐American adults but replication in other studies is inconsistent and may be attributed to gene‐by‐age effects. The aims of this study were to determine if the influence of the summed risk score of these 32 loc...

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Published in:Obesity (Silver Spring, Md.) Md.), 2014-03, Vol.22 (3), p.875-881
Main Authors: Choh, Audrey C., Lee, Miryoung, Kent, Jack W., Diego, Vincent P., Johnson, William, Curran, Joanne E., Dyer, Thomas D., Bellis, Claire, Blangero, John, Siervogel, Roger M., Towne, Bradford, Demerath, Ellen W., Czerwinski, Stefan A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aging
Biomedical research
Body Mass Index
Child
Child development
Child, Preschool
Female
Genes
Genetic Loci
Genetic Predisposition to Disease
Genome-Wide Association Study - methods
Genomes
Genomics
Humans
Infant
Influence
Longitudinal Studies
Male
Medical research
Obesity
Obesity - genetics
Ohio
Polymorphism, Single Nucleotide
Quantitative genetics
Studies
Whites - genetics
Young Adult
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Summary:Objectives Genome wide association studies have shown 32 loci to influence BMI in European‐American adults but replication in other studies is inconsistent and may be attributed to gene‐by‐age effects. The aims of this study were to determine if the influence of the summed risk score of these 32 loci (GRS) on BMI differed across age from birth to 40 years, and to determine if additive genetic effects other than those in the GRS differed by age. Methods Serial measures of BMI were calculated at 0, 1, 3, 6, 9, 12, 18, and 28 months, and 4, 7, 11, 15, 19, 23, 30, and 40 years for 1,176 (605 females, 571 males) European‐American participants in the Fels Longitudinal Study. SOLAR was used for genetic analyses. Results GRS was significant (P < 0.05) at ages: 6, 9 months, 4‐15 years, and 23‐40 years. Remaining additive genetic effects independently influenced BMI (P < 5.3 × 10−5, 0.40 < h2 < 0.76). Some genetic correlations between ages were not significant. Differential GRS effects did not retain significance after multiple comparisons adjustments. Conclusions While well‐known BMI variants do not appear to have significant differential effects, other additive genes differ over the lifespan.
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.20517