Re-evaluation of ABO gene polymorphisms detected in a genome- wide association study and risk of pancreatic ductal adenocarcinoma in a Chinese population

Pancreatic cancer is a fatal malignancy with an increasing incidence in Shanghai, China. A genome wide association study （GWAS） and other work have shown that ABO alleles are associated with pancreatic cancer risk. We conducted a population-based case-control study involving 256 patients with pathol...

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Bibliographic Details
Published in:Ai zheng 2014-02, Vol.33 (2), p.68-73
Main Authors: Xu, Hong-Li, Cheng, Jia-Rong, Zhang, Wei, Wang, Jing, Yu, Herbert, Ni, Quan-Xing, Risch, Harvey A, Gao, Yu-Tang
Format: Article
Language:English
Subjects:
ABO Blood-Group System - genetics
Adenocarcinoma - genetics
Aged
Alleles
Asian Continental Ancestry Group - genetics
Case-Control Studies
China
Confidence Intervals
Female
Gene-Environment Interaction
Genome-Wide Association Study
Genotype
Haplotypes
Humans
Male
Middle Aged
Odds Ratio
Pancreatic Neoplasms - genetics
Polymorphism, Single Nucleotide
Review
Risk Factors
中国人群
全基因组
关联
基因多态性
导管
胰腺癌
评估
风险
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Summary:Pancreatic cancer is a fatal malignancy with an increasing incidence in Shanghai, China. A genome wide association study （GWAS） and other work have shown that ABO alleles are associated with pancreatic cancer risk. We conducted a population-based case-control study involving 256 patients with pathologically confirmed pancreatic ductal adenocarcinoma （PDAC） and 548 healthy controls in Shanghai, China, to assess the relationships between GWAS-identified ABO alleles and risk of PDAC. Carriers of the C allele of rs505922 had an increased cancer risk [adjusted odds ratio （OR） = 1.42, 95% confidence interval （CI）： 1.02-1.98] compared to TT carriers. The T alleles of rs495828 and rs657152 were also significantly associated with an elevated cancer risk （adjusted OR = 1.58, 95% CI： 1.17-2.14; adjusted OR = 1.51, 95% CI： 1.09-2.10）. The rs630014 variant was not associated with risk. We did not find any significant gene-environment interaction with cancer risk using a multifactor dimensionality reduction （MDR） method. Haplotype analysis also showed that the haplotype CTTC was associated with an increased risk of PDAC （adjusted OR = 1.46, 95% CI： 1.12-1.91） compared with haplotype TGGT. GWAS-identified ABO variants are thus also associated with risk of PDAC in the Chinese population.
ISSN:1000-467X
1944-446X
DOI:10.5732/cjc.013.10060