Polyunsaturated Fatty Acids and Their Relation with Bone and Muscle Health in Adults

Age-related bone and muscle loss are major public health problems. Investigational therapies to reduce these losses include anti-inflammatory dietary supplementations, such as polyunsaturated fatty acids (PUFA). Surprisingly, this topic has received little attention in the osteoporosis community. Re...

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Bibliographic Details
Published in:Current osteoporosis reports 2013-09, Vol.11 (3), p.203-212
Main Authors: Mangano, Kelsey M., Sahni, Shivani, Kerstetter, Jane E., Kenny, Anne M., Hannan, Marian T.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging - drug effects
Aging - physiology
Bone and Bones - drug effects
Bone and Bones - physiology
Bone Density - drug effects
Bone Density - physiology
Bone Resorption - epidemiology
Bone Resorption - prevention & control
Dietary Supplements
Epidemiology
Fatty Acids, Unsaturated - pharmacology
Fatty Acids, Unsaturated - therapeutic use
Female
Fractures, Bone - epidemiology
Fractures, Bone - prevention & control
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Muscle, Skeletal - drug effects
Muscle, Skeletal - physiology
Nutrition and Lifestyle in Osteoporosis (S Ferrari
Orthopedics
Risk Factors
Section Editor
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Summary:Age-related bone and muscle loss are major public health problems. Investigational therapies to reduce these losses include anti-inflammatory dietary supplementations, such as polyunsaturated fatty acids (PUFA). Surprisingly, this topic has received little attention in the osteoporosis community. Recent research highlights the role of PUFA in inflammatory regulation of bone remodeling via cellular pathways. Emerging research suggests significant roles for PUFA in reducing bone and muscle loss with aging; however, findings are conflicted for PUFA and fracture risk. Limited studies suggest a relation between higher omega-3 FA and better muscle/bone in older adults. This review highlights new research since 2008 and synthesizes our current understanding of PUFA in relation to bone and muscle. Across study designs, evidence indicates that PUFA has positive effects upon bone. As data are sparse, future clinical trials and prospective studies are important to determine the long term benefits of PUFA supplementation upon bone and muscle outcomes.
ISSN:1544-1873
1544-2241
DOI:10.1007/s11914-013-0149-0