Loading…

Developmental outcomes of children with congenital diaphragmatic hernia: A multicenter prospective study

Abstract Purpose To determine developmental outcomes and associated factors in patients with congenital diaphragmatic hernia (CDH) at 2 years of age. Methods This is a multicenter prospective study of a CDH birth cohort. Clinical and socioeconomic data were collected. Bayley Scales of Infant Develop...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pediatric surgery 2013-10, Vol.48 (10), p.1995-2004
Main Authors: Wynn, Julia, Aspelund, Gudrun, Zygmunt, Annette, Stolar, Charles J.H, Mychaliska, George, Butcher, Jennifer, Lim, Foong-Yen, Gratton, Teresa, Potoka, Douglas, Brennan, Kate, Azarow, Ken, Jackson, Barbara, Needelman, Howard, Crombleholme, Timothy, Zhang, Yuan, Duong, Jimmy, Arkovitz, Marc S, Chung, Wendy K, Farkouh, Christiana
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Purpose To determine developmental outcomes and associated factors in patients with congenital diaphragmatic hernia (CDH) at 2 years of age. Methods This is a multicenter prospective study of a CDH birth cohort. Clinical and socioeconomic data were collected. Bayley Scales of Infant Development (BSID-III) and Vineland Adaptive Behavior Scales (VABS-II) were performed at 2 years of age. Results BSID-III and VABS-II assessments were completed on 48 and 49 children, respectively. The BSID-III mean cognitive, language, and motor scores were significantly below the norm mean with average scores of 93 ± 15, 95 ± 16, and 95 ± 11. Ten percent (5/47) scored more than 2 standard deviations below the norm on one or more domains. VABS-II scores were similar to BSID-III scores with mean communication, daily living skills, social, motor, adaptive behavior scores of 97 ± 14, 94 ± 16, 93 ± 13, 97 ± 10, and 94 ± 14. For the BSID-III, supplemental oxygen at 28 days, a prenatal diagnosis, need for extracorporeal membrane oxygenation (ECMO) and exclusive tube feeds at time of discharge were associated with lower scores. At 2 years of age, history of hospital readmission and need for tube feeds were associated with lower scores. Lower socioeconomic status correlated with lower developmental scores when adjusted for significant health factors. Conclusion CDH patients on average have lower developmental scores at 2 years of age compared to the norm. A need for ECMO, oxygen at 28 days of life, ongoing health issues and lower socioeconomic status are factors associated with developmental delays.
ISSN:0022-3468
1531-5037
DOI:10.1016/j.jpedsurg.2013.02.041