A reanalysis of cancer mortality in Canadian nuclear workers (1956–1994) based on revised exposure and cohort data

Background: A 15-country study of nuclear workers reported significantly increased radiation-related risks of all cancers excluding leukaemia, with Canadian data a major factor behind the pooled results. We analysed mortality (1956–1994) in the updated Canadian cohort and provided revised risk estim...

Full description

Saved in:
Bibliographic Details
Published in:British journal of cancer 2014-01, Vol.110 (1), p.214-223
Main Authors: Zablotska, L B, Lane, R S D, Thompson, P A
Format: Article
Language:English
Subjects:
692/699/67/2324
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Canada - epidemiology
Cancer
Cancer Research
Cohort Studies
Dose-Response Relationship, Radiation
Dosimetry
Drug Resistance
Employment
Epidemiology
Estimates
Female
Humans
Leukemia
Male
Medical research
Medical sciences
Models, Statistical
Molecular Medicine
Mortality
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Neoplasms, Radiation-Induced - mortality
Nuclear accidents & safety
Nuclear power plants
Nuclear Power Plants - statistics & numerical data
Occupational Diseases - etiology
Occupational Diseases - mortality
Occupational Exposure - analysis
Oncology
Radiation
Socioeconomic factors
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: A 15-country study of nuclear workers reported significantly increased radiation-related risks of all cancers excluding leukaemia, with Canadian data a major factor behind the pooled results. We analysed mortality (1956–1994) in the updated Canadian cohort and provided revised risk estimates. Methods: Employment records were searched to verify and revise exposure data and to restore missing socioeconomic status. Excess relative risks per sievert (ERR/Sv) of recorded radiation dose and 95% confidence intervals (CIs) were estimated using Poisson regression. Results: A significant heterogeneity of the dose–response for solid cancer was identified ( P =0.02), with 3088 early (1956–1964) Atomic Energy of Canada Limited (AECL) workers having a significant increase (ERR/Sv=7.87, 95% CI: 1.88, 19.5), and no evidence of radiation risk for 42 228 workers employed by three nuclear power plant companies and post-1964 AECL (ERR/Sv=−1.20, 95% CI:
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.2013.592