Elevated CNS Inflammation in Patients with Preclinical Alzheimer's Disease

Alzheimer's disease (AD) is a progressive, neurodegenerative disease that may involve inflammatory responses in the central nervous system (CNS). Our objective was to determine whether patients with amnestic mild cognitive impairment (aMCI), a preclinical stage of AD, have inflammatory characte...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 2014-01, Vol.34 (1), p.30-33
Main Authors: Monson, Nancy L, Ireland, Sara J, Ligocki, Ann J, Chen, Ding, Rounds, William H, Li, Min, Huebinger, Ryan M, Munro Cullum, C, Greenberg, Benjamin M, Stowe, Ann M, Zhang, Rong
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - cerebrospinal fluid
Alzheimer Disease - immunology
Alzheimer's disease
Brief Communication
Case-Control Studies
Cell Lineage
Cognitive Dysfunction - cerebrospinal fluid
Cognitive Dysfunction - immunology
Cytokines - cerebrospinal fluid
Cytokines - immunology
Demyelinating Diseases - cerebrospinal fluid
Demyelinating Diseases - immunology
Humans
Lymphocytes - cytology
Lymphocytes - immunology
Middle Aged
Multiple Sclerosis - cerebrospinal fluid
Multiple Sclerosis - immunology
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Summary:Alzheimer's disease (AD) is a progressive, neurodegenerative disease that may involve inflammatory responses in the central nervous system (CNS). Our objective was to determine whether patients with amnestic mild cognitive impairment (aMCI), a preclinical stage of AD, have inflammatory characteristics similar to patients with multiple sclerosis (MS), a known CNS inflammatory disease. The frequency of lymphocytes and levels of pro-inflammatory cytokines in the cerebrospinal fluid of aMCI patients was comparable to MS patients or patients at high risk to develop MS. Thus, brain inflammation occurs early at the preclinical stage of AD and may have an important role in pathology.
ISSN:0271-678X
1559-7016
DOI:10.1038/jcbfm.2013.183