Isolation of tracheal aspirate mesenchymal stromal cells predicts bronchopulmonary dysplasia

We have isolated mesenchymal stem cells (MSCs) from tracheal aspirates of premature infants with respiratory distress. Under the influence of transforming growth factor β, MSCs differentiate into α-smooth-muscle actin-expressing myofibroblasts. Myofibroblasts are increased in the lungs of patients w...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2010-11, Vol.126 (5), p.e1127-e1133
Main Authors: Popova, Antonia P, Bozyk, Paul D, Bentley, J Kelley, Linn, Marisa J, Goldsmith, Adam M, Schumacher, Robert E, Weiner, Gary M, Filbrun, Amy G, Hershenson, Marc B
Format: Article
Language:English
Subjects:
Babies
Birth Weight
Bronchopulmonary Dysplasia - diagnosis
Bronchopulmonary Dysplasia - mortality
Bronchopulmonary Dysplasia - pathology
Early Diagnosis
Female
Gestational Age
Humans
Infant, Newborn
Infant, Very Low Birth Weight
Lung diseases
Male
Mesenchymal Stromal Cells - pathology
Pathogenesis
Pediatrics
Prognosis
Reference Values
Respiratory Distress Syndrome, Newborn - diagnosis
Respiratory Distress Syndrome, Newborn - mortality
Respiratory Distress Syndrome, Newborn - pathology
Respiratory system
Secretory Component - analysis
Sex Factors
Stem Cells
Stromal Cells - pathology
Suction
Survival Rate
Trachea - pathology
Transforming Growth Factor beta1 - analysis
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Summary:We have isolated mesenchymal stem cells (MSCs) from tracheal aspirates of premature infants with respiratory distress. Under the influence of transforming growth factor β, MSCs differentiate into α-smooth-muscle actin-expressing myofibroblasts. Myofibroblasts are increased in the lungs of patients with bronchopulmonary dysplasia (BPD), a chronic lung disease of prematurely born infants. We tested whether isolation of MSCs from tracheal aspirates of premature infants with respiratory distress during the first week of life correlates with BPD. Eighty-four infants born at a gestational age of
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2009-3445