Immunochemical Characterization of Murine H-2 Controlled Ss (Serum Substance) Protein through Identification of its Human Homologue as the Fourth Component of Complement

The S region of the mouse H-2 complex is genetically defined by a series of alleles, or pseudoalleles, which control the level of a serum globulin, Ss, and of its allotypic variant, Slp. In contrast with the products of other genes in the complex, no homologue of the Ss protein has been found in oth...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1975-11, Vol.72 (11), p.4536-4540
Main Authors: Meo, Tommaso, Krasteff, T., Shreffler, D. C.
Format: Article
Language:English
Subjects:
Alleles
Animals
Beta-Globulins - analysis
Beta-Globulins - immunology
Blood plasma
Complement C4 - analysis
Complement System Proteins - analysis
Cross Reactions
Evolutionary genetics
Gels
Genes
Genetic Linkage
Genetic loci
Histocompatibility Antigens
Human genetics
Humans
Immunodiffusion
Medical genetics
Mice
Mice, Inbred Strains
Precipitins
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Description
Summary:The S region of the mouse H-2 complex is genetically defined by a series of alleles, or pseudoalleles, which control the level of a serum globulin, Ss, and of its allotypic variant, Slp. In contrast with the products of other genes in the complex, no homologue of the Ss protein has been found in other species, except the rat. In the present study, a component in human plasma was identified which cross-reacts with anti-mouse Ss, and which also displays electrophoretic and size similarities to the mouse Ss protein. This component was isolated and characterized immunochemically as the fourth component of human complement (C′4 or β 1E globulin). Several antisera monospecific for human C′4 cross-react with the mouse Ss protein and detect its genetically determined quantitative variations.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.72.11.4536