Mathematical Model of Dynamic Protein Interactions Regulating p53 Protein Stability for Tumor Suppression

In the field of cancer biology, numerous genes or proteins form extremely complex regulatory network, which determines cancer cell fate and cancer cell survival. p53 is a major tumor suppressor that is lost in more than 50% of human cancers. It has been well known that a variety of proteins regulate...

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Bibliographic Details
Published in:Computational and mathematical methods in medicine 2013-01, Vol.2013 (2013), p.1-6
Main Authors: Wang, Hua, Peng, Guang
Format: Article
Language:English
Subjects:
Algorithms
Cell Cycle
Computational Biology
DNA Damage
Gene Expression Profiling
Gene Expression Regulation
Genes, Tumor Suppressor
Histone Deacetylase 1 - metabolism
Humans
Models, Biological
Neoplasms - metabolism
Protein Interaction Mapping
Protein Stability
Signal Transduction
Software
Tumor Suppressor Protein p53 - metabolism
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Summary:In the field of cancer biology, numerous genes or proteins form extremely complex regulatory network, which determines cancer cell fate and cancer cell survival. p53 is a major tumor suppressor that is lost in more than 50% of human cancers. It has been well known that a variety of proteins regulate its protein stability, which is essential for its tumor suppressive function. It remains elusive how we could understand and target p53 stabilization process through network analysis. In this paper we discuss the use of random walk and stationary distribution to measure the compound effect of a network of genes or proteins. This method is applied to the network of nine proteins that influence the protein stability of p53 via regulating the interaction between p53 and its regulator MDM2. Our study identifies that some proteins such as HDAC1 in the network of p53 regulators may have more profound effects on p53 stability, agreeing with the established findings on HDAC1. This work shows the importance of using mathematical analysis to dissect the complexity of biology networks in cancer.
ISSN:1748-670X
1748-6718
DOI:10.1155/2013/358980