Tissue-type plasminogen activator mediates neuroglial coupling in the central nervous system

Highlights • Metabolic stress induces rapid release of tissue-type plasminogen activator (tPA) from cerebrocortical neurons. • Neuronal tPA activates a signaling pathway in astrocytes that induces the uptake of glucose and the release of lactic acid. • The uptake of lactic acid by neurons promotes s...

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Bibliographic Details
Published in:Neuroscience 2014-01, Vol.257, p.41-48
Main Authors: An, J, Haile, W.B, Wu, F, Torre, E, Yepes, M
Format: Article
Language:English
Subjects:
AMP-Activated Protein Kinases - metabolism
Animals
Animals, Newborn
Arabinose - pharmacology
Biological and medical sciences
Cell Death - drug effects
Cells, Cultured
Cerebral Cortex - cytology
Dose-Response Relationship, Drug
Embryo, Mammalian
Fundamental and applied biological sciences. Psychology
Glial Fibrillary Acidic Protein - metabolism
Glucose - deficiency
Glucose - metabolism
Glucose Transporter Type 1 - metabolism
Hypoxia - physiopathology
Imino Furanoses - pharmacology
Lactic Acid - metabolism
Mice
Neuroglia - drug effects
Neuroglia - metabolism
Neurology
Neurons - drug effects
Neurons - metabolism
Sugar Alcohols - pharmacology
Time Factors
Tissue Plasminogen Activator - pharmacology
Vertebrates: nervous system and sense organs
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Summary:Highlights • Metabolic stress induces rapid release of tissue-type plasminogen activator (tPA) from cerebrocortical neurons. • Neuronal tPA activates a signaling pathway in astrocytes that induces the uptake of glucose and the release of lactic acid. • The uptake of lactic acid by neurons promotes survival in cells exposed to oxygen and glucose deprivation conditions.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.10.060