Escherichia coli Dysbiosis Correlates With Gastrointestinal Dysfunction in Children With Cystic Fibrosis

Cystic fibrosis gastrointestinal disease includes nutrient malabsorption and intestinal inflammation. We show that the abundances of Escherichia coli in fecal microbiota were significantly higher in young children with cystic fibrosis than in controls and correlated with fecal measures of nutrient m...

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Bibliographic Details
Published in:Clinical infectious diseases 2014-02, Vol.58 (3), p.396-399
Main Authors: Hoffman, Lucas R., Pope, Christopher E., Hayden, Hillary S., Heltshe, Sonya, Levy, Roie, McNamara, Sharon, Jacobs, Michael A., Rohmer, Laurence, Radey, Matthew, Ramsey, Bonnie W., Brittnacher, Mitchell J., Borenstein, Elhanan, Miller, Samuel I.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Antibiotics
Biological and medical sciences
BRIEF REPORT
Brief Reports
Child
Child nutrition disorders
Child, Preschool
Children
Correlation analysis
Cystic fibrosis
Cystic Fibrosis - complications
Dysbiosis - complications
Dysbiosis - microbiology
E coli
Errors of metabolism
Escherichia coli
Escherichia coli Infections - complications
Escherichia coli Infections - microbiology
Feces - microbiology
Female
Gastrointestinal diseases
Gastrointestinal Diseases - etiology
Gastrointestinal Diseases - microbiology
Gastrointestinal Diseases - pathology
Gastrointestinal tract
Humans
Infant
Infant, Newborn
Infectious diseases
Inflammation
Male
Medical sciences
Metabolic diseases
Metagenomics
Microbiota
Middle Aged
Miscellaneous hereditary metabolic disorders
Young Adult
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Description
Summary:Cystic fibrosis gastrointestinal disease includes nutrient malabsorption and intestinal inflammation. We show that the abundances of Escherichia coli in fecal microbiota were significantly higher in young children with cystic fibrosis than in controls and correlated with fecal measures of nutrient malabsorption and inflammation, suggesting that E. coli could contribute to cystic fibrosis gastrointestinal dysfunction.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/cit715