Indomethacin and ketorolac given preoperatively are equally effective in reducing early postoperative pain after laparoscopic cholecystectomy

• Published in: Canadian journal of surgery 1996-02, Vol.39 (1), p.26-30
• Main Authors: Forse, A, El-Beheiry, H, Butler, P O, Pace, R F
• Format: Article
• Language: English
• Subjects: Adult; Aged; Analgesics, Non-Narcotic - administration & dosage; Analgesics, Non-Narcotic - therapeutic use; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Cholecystectomy, Laparoscopic; Cholelithiasis - surgery; Double-Blind Method; Female; Humans; Indomethacin - administration & dosage; Indomethacin - therapeutic use; Ketorolac; Male; Original; Pain, Postoperative - prevention & control; Preoperative Care; Prospective Studies; Tolmetin - administration & dosage; Tolmetin - analogs & derivatives; Tolmetin - therapeutic use
• ISSN: 0008-428X; 1488-2310

To evaluate the efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) on pain after laparoscopic cholecystectomy. A prospective, randomized, placebo-controlled, double-blind study. A university hospital. Fifty-two patients with cholelithiasis but without known allergy to one of the study drugs, history of bleeding, peptic ulcer disease, known cardiac, lung or renal disease, abnormal liver function or use of opiates or NSAIDs within 2 weeks before operation. Patients were assigned to one of three groups and treatment was randomized by placing the drugs in sealed, numbered envelopes. Administration of the NSAIDs ketorolac, intramuscularly, or indomethacin, rectally, before laparoscopic cholecystectomy. Postoperative pain scored on a a visual analogue scale and by nurse assessment, total dose of fentanyl citrate given, and nausea or emesis. Patients in the placebo group reported significantly more pain than either NSAID group (p