Predictors of response to palliative care intervention for chronic nausea in advanced cancer outpatients

Purpose Nausea is a frequent and distressing symptom in advanced cancer patients. The objective of this retrospective study was to determine predictors of response to palliative care consultation for chronic nausea in advanced cancer outpatients. Methods Eligible patients included were outpatient su...

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Bibliographic Details
Published in:Supportive care in cancer 2013-09, Vol.21 (9), p.2427-2435
Main Authors: Rhondali, Wadih, Yennurajalingam, Sriram, Chisholm, Gary, Ferrer, Jeanette, Kim, Sun Hyun, Kang, Jung Hun, Filbet, Marilene, Bruera, Eduardo
Format: Article
Language:English
Subjects:
Aged
Ambulatory Care
Analgesics, Opioid - therapeutic use
Analysis
Antiemetics - therapeutic use
Cancer
Cancer patients
Cancer research
Chronic Disease
Constipation
Development and progression
Fatigue
Fatigue - chemically induced
Fatigue - diagnosis
Fatigue - epidemiology
Female
Follow-Up Studies
Humans
Intervention
Laxatives - therapeutic use
Logistic Models
Male
Medical research
Medical schools
Medicine & Public Health
Middle Aged
Nausea
Nausea - chemically induced
Nausea - drug therapy
Nausea - epidemiology
Neoplasms - drug therapy
Neoplasms - epidemiology
Nursing
Nursing Research
Oncology
Original Article
Outpatients
Pain Medicine
Palliative care
Palliative Care - methods
Palliative treatment
Predictive Value of Tests
Rehabilitation Medicine
Retrospective Studies
Risk Factors
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Summary:Purpose Nausea is a frequent and distressing symptom in advanced cancer patients. The objective of this retrospective study was to determine predictors of response to palliative care consultation for chronic nausea in advanced cancer outpatients. Methods Eligible patients included were outpatient supportive care center seen consecutively for an initial consultation and who had one follow-up visit within 30 days of the initial consultation. We reviewed the medical records of 1,273 consecutive patients, and 444 (35 %) were found to meet the eligibility criteria. All patients were assessed using the Edmonton Symptom Assessment Scale (ESAS). Nausea response was defined as an improvement of at least 30 % between the initial visit and the first follow-up. We used logistic regression models to assess the possible predictors of improvement in nausea. Results Overall, 112 of 444 patients (25 %) experienced moderate/severe chronic nausea (ESAS item score ≥4/10). Higher baseline nausea intensity was significantly related to constipation ( r  = 0.158; p  = 0.046) and all the symptoms assessed by the ESAS ( p  
ISSN:0941-4355
1433-7339
DOI:10.1007/s00520-013-1805-8