No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population

• Published in: Human genetics 2013-12, Vol.132 (12), p.1427-1431
• Main Authors: Dumitrescu, Logan, Carty, Cara L., Franceschini, Nora, Hindorff, Lucia A., Cole, Shelley A., Bůžková, Petra, Schumacher, Fredrick R., Eaton, Charles B., Goodloe, Robert J., Duggan, David J., Haessler, Jeff, Cochran, Barbara, Henderson, Brian E., Cheng, Iona, Johnson, Karen C., Carlson, Chris S., Love, Shelly-Anne, Brown-Gentry, Kristin, Nato, Alejandro Q., Quibrera, Miguel, Shohet, Ralph V., Ambite, José Luis, Wilkens, Lynne R., Le Marchand, Loïc, Haiman, Christopher A., Buyske, Steven, Kooperberg, Charles, North, Kari E., Fornage, Myriam, Crawford, Dana C.
• Format: Article
• Language: English
• Subjects: Analysis; Biomedical and Life Sciences; Biomedicine; Cancer research; Cholesterol; Cholesterol, HDL - metabolism; Cholesterol, LDL - metabolism; Cohort Studies; Epidemiology; Ethnicity - genetics; Female; Gene Frequency; Gene Function; Gene-Environment Interaction; Genetic research; Genetics; Genetics, Population; Genome-Wide Association Study - statistics & numerical data; Genomes; Genomics; Health care; High density lipoprotein; Hispanic people; Human Genetics; Humans; Lipid Metabolism - genetics; Lipids; Lipoproteins; Low density lipoproteins; Male; Medical research; Metabolic Diseases; Molecular Medicine; Polymorphism, Single Nucleotide; Population; Prevalence; Preventive medicine; Public health; Short Report; Smoking - epidemiology; Smoking - ethnology; Smoking - genetics; Smoking - metabolism; Triglycerides; Triglycerides - metabolism; Young Adult
• ISSN: 0340-6717; 1432-1203; 1432-1203
• DOI: 10.1007/s00439-013-1375-3

Genome-wide association studies (GWAS) have identified many variants that influence high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and/or triglycerides. However, environmental modifiers, such as smoking, of these known genotype–phenotype associations are just recently emerging in the literature. We have tested for interactions between smoking and 49 GWAS-identified variants in over 41,000 racially/ethnically diverse samples with lipid levels from the Population Architecture Using Genomics and Epidemiology (PAGE) study. Despite their biological plausibility, we were unable to detect significant SNP × smoking interactions.