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No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population
Genome-wide association studies (GWAS) have identified many variants that influence high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and/or triglycerides. However, environmental modifiers, such as smoking, of these known genotype–phenotype associations are just recently eme...
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| Published in: | Human genetics 2013-12, Vol.132 (12), p.1427-1431 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c571t-fc2f94a2410ee88421e04030da1a03c4f819df2bc904b98580d43effe2a496833 |
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| cites | cdi_FETCH-LOGICAL-c571t-fc2f94a2410ee88421e04030da1a03c4f819df2bc904b98580d43effe2a496833 |
| container_end_page | 1431 |
| container_issue | 12 |
| container_start_page | 1427 |
| container_title | Human genetics |
| container_volume | 132 |
| creator | Dumitrescu, Logan Carty, Cara L. Franceschini, Nora Hindorff, Lucia A. Cole, Shelley A. Bůžková, Petra Schumacher, Fredrick R. Eaton, Charles B. Goodloe, Robert J. Duggan, David J. Haessler, Jeff Cochran, Barbara Henderson, Brian E. Cheng, Iona Johnson, Karen C. Carlson, Chris S. Love, Shelly-Anne Brown-Gentry, Kristin Nato, Alejandro Q. Quibrera, Miguel Shohet, Ralph V. Ambite, José Luis Wilkens, Lynne R. Le Marchand, Loïc Haiman, Christopher A. Buyske, Steven Kooperberg, Charles North, Kari E. Fornage, Myriam Crawford, Dana C. |
| description | Genome-wide association studies (GWAS) have identified many variants that influence high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and/or triglycerides. However, environmental modifiers, such as smoking, of these known genotype–phenotype associations are just recently emerging in the literature. We have tested for interactions between smoking and 49 GWAS-identified variants in over 41,000 racially/ethnically diverse samples with lipid levels from the Population Architecture Using Genomics and Epidemiology (PAGE) study. Despite their biological plausibility, we were unable to detect significant SNP × smoking interactions. |
| doi_str_mv | 10.1007/s00439-013-1375-3 |
| format | article |
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However, environmental modifiers, such as smoking, of these known genotype–phenotype associations are just recently emerging in the literature. We have tested for interactions between smoking and 49 GWAS-identified variants in over 41,000 racially/ethnically diverse samples with lipid levels from the Population Architecture Using Genomics and Epidemiology (PAGE) study. Despite their biological plausibility, we were unable to detect significant SNP × smoking interactions.</description><identifier>ISSN: 0340-6717</identifier><identifier>ISSN: 1432-1203</identifier><identifier>EISSN: 1432-1203</identifier><identifier>DOI: 10.1007/s00439-013-1375-3</identifier><identifier>PMID: 24100633</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analysis ; Biomedical and Life Sciences ; Biomedicine ; Cancer research ; Cholesterol ; Cholesterol, HDL - metabolism ; Cholesterol, LDL - metabolism ; Cohort Studies ; Epidemiology ; Ethnicity - genetics ; Female ; Gene Frequency ; Gene Function ; Gene-Environment Interaction ; Genetic research ; Genetics ; Genetics, Population ; Genome-Wide Association Study - statistics & numerical data ; Genomes ; Genomics ; Health care ; High density lipoprotein ; Hispanic people ; Human Genetics ; Humans ; Lipid Metabolism - genetics ; Lipids ; Lipoproteins ; Low density lipoproteins ; Male ; Medical research ; Metabolic Diseases ; Molecular Medicine ; Polymorphism, Single Nucleotide ; Population ; Prevalence ; Preventive medicine ; Public health ; Short Report ; Smoking - epidemiology ; Smoking - ethnology ; Smoking - genetics ; Smoking - metabolism ; Triglycerides ; Triglycerides - metabolism ; Young Adult</subject><ispartof>Human genetics, 2013-12, Vol.132 (12), p.1427-1431</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><rights>COPYRIGHT 2013 Springer</rights><rights>Springer-Verlag Berlin Heidelberg 2013 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c571t-fc2f94a2410ee88421e04030da1a03c4f819df2bc904b98580d43effe2a496833</citedby><cites>FETCH-LOGICAL-c571t-fc2f94a2410ee88421e04030da1a03c4f819df2bc904b98580d43effe2a496833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24100633$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dumitrescu, Logan</creatorcontrib><creatorcontrib>Carty, Cara L.</creatorcontrib><creatorcontrib>Franceschini, Nora</creatorcontrib><creatorcontrib>Hindorff, Lucia A.</creatorcontrib><creatorcontrib>Cole, Shelley A.</creatorcontrib><creatorcontrib>Bůžková, Petra</creatorcontrib><creatorcontrib>Schumacher, Fredrick R.</creatorcontrib><creatorcontrib>Eaton, Charles B.</creatorcontrib><creatorcontrib>Goodloe, Robert J.</creatorcontrib><creatorcontrib>Duggan, David J.</creatorcontrib><creatorcontrib>Haessler, Jeff</creatorcontrib><creatorcontrib>Cochran, Barbara</creatorcontrib><creatorcontrib>Henderson, Brian E.</creatorcontrib><creatorcontrib>Cheng, Iona</creatorcontrib><creatorcontrib>Johnson, Karen C.</creatorcontrib><creatorcontrib>Carlson, Chris S.</creatorcontrib><creatorcontrib>Love, Shelly-Anne</creatorcontrib><creatorcontrib>Brown-Gentry, Kristin</creatorcontrib><creatorcontrib>Nato, Alejandro Q.</creatorcontrib><creatorcontrib>Quibrera, Miguel</creatorcontrib><creatorcontrib>Shohet, Ralph V.</creatorcontrib><creatorcontrib>Ambite, José Luis</creatorcontrib><creatorcontrib>Wilkens, Lynne R.</creatorcontrib><creatorcontrib>Le Marchand, Loïc</creatorcontrib><creatorcontrib>Haiman, Christopher A.</creatorcontrib><creatorcontrib>Buyske, Steven</creatorcontrib><creatorcontrib>Kooperberg, Charles</creatorcontrib><creatorcontrib>North, Kari E.</creatorcontrib><creatorcontrib>Fornage, Myriam</creatorcontrib><creatorcontrib>Crawford, Dana C.</creatorcontrib><title>No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population</title><title>Human genetics</title><addtitle>Hum Genet</addtitle><addtitle>Hum Genet</addtitle><description>Genome-wide association studies (GWAS) have identified many variants that influence high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and/or triglycerides. However, environmental modifiers, such as smoking, of these known genotype–phenotype associations are just recently emerging in the literature. We have tested for interactions between smoking and 49 GWAS-identified variants in over 41,000 racially/ethnically diverse samples with lipid levels from the Population Architecture Using Genomics and Epidemiology (PAGE) study. Despite their biological plausibility, we were unable to detect significant SNP × smoking interactions.</description><subject>Analysis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer research</subject><subject>Cholesterol</subject><subject>Cholesterol, HDL - metabolism</subject><subject>Cholesterol, LDL - metabolism</subject><subject>Cohort Studies</subject><subject>Epidemiology</subject><subject>Ethnicity - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Gene Function</subject><subject>Gene-Environment Interaction</subject><subject>Genetic research</subject><subject>Genetics</subject><subject>Genetics, Population</subject><subject>Genome-Wide Association Study - statistics & numerical data</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Health care</subject><subject>High density lipoprotein</subject><subject>Hispanic people</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Lipid Metabolism - genetics</subject><subject>Lipids</subject><subject>Lipoproteins</subject><subject>Low density lipoproteins</subject><subject>Male</subject><subject>Medical research</subject><subject>Metabolic Diseases</subject><subject>Molecular Medicine</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population</subject><subject>Prevalence</subject><subject>Preventive medicine</subject><subject>Public health</subject><subject>Short Report</subject><subject>Smoking - epidemiology</subject><subject>Smoking - ethnology</subject><subject>Smoking - genetics</subject><subject>Smoking - metabolism</subject><subject>Triglycerides</subject><subject>Triglycerides - metabolism</subject><subject>Young Adult</subject><issn>0340-6717</issn><issn>1432-1203</issn><issn>1432-1203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1kktv1DAUhSMEotPCD2CDLLGhixS_Mok3SKOqlEoVIB5ry-NcZ9wmdrCdKfDrcZhSOgjkhSXf75zre3WK4hnBJwTj-lXEmDNRYsJKwuqqZA-KBeGMloRi9rBYYMZxuaxJfVAcxniFMakErR4XB5Rn_ZKxRfHjnUewtS04DcgbZF2CoHSy3qE1pBsAh66dv3Got6NtSxWj11YlaFEHDpLVaKuCVS5FpFyL4uCvreuyD0obQMPUJ1tC2rgMflidn6HRj1OvZv8nxSOj-ghPb--j4subs8-nb8vL9-cXp6vLUlc1SaXR1Aiu5i8DNA2nBDDHDLeKKMw0Nw0RraFrLTBfi6ZqcMsZGANUcbFsGDsqXu98x2k9QKvBpaB6OQY7qPBdemXlfsXZjez8VrJGVIzV2eDlrUHwXyeISQ42auh75cBPURJeNaSpyS_0xV_olZ-Cy-NligtBOV_yP1SnepDWGZ_76tlUrlhF64phQTN18g8qnxYGq70DY_P7nuB4T5CZBN9Sp6YY5cWnj_ss2bE6-BgDmLt9ECzncMlduGQOl5zDJedFPr-_yDvF7zRlgO6AmEuug3Bv-v-6_gSD4tkn</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Dumitrescu, Logan</creator><creator>Carty, Cara L.</creator><creator>Franceschini, Nora</creator><creator>Hindorff, Lucia A.</creator><creator>Cole, Shelley A.</creator><creator>Bůžková, Petra</creator><creator>Schumacher, Fredrick R.</creator><creator>Eaton, Charles B.</creator><creator>Goodloe, Robert J.</creator><creator>Duggan, David J.</creator><creator>Haessler, Jeff</creator><creator>Cochran, Barbara</creator><creator>Henderson, Brian E.</creator><creator>Cheng, Iona</creator><creator>Johnson, Karen C.</creator><creator>Carlson, Chris S.</creator><creator>Love, Shelly-Anne</creator><creator>Brown-Gentry, Kristin</creator><creator>Nato, Alejandro Q.</creator><creator>Quibrera, Miguel</creator><creator>Shohet, Ralph V.</creator><creator>Ambite, José Luis</creator><creator>Wilkens, Lynne R.</creator><creator>Le Marchand, Loïc</creator><creator>Haiman, Christopher A.</creator><creator>Buyske, Steven</creator><creator>Kooperberg, Charles</creator><creator>North, Kari E.</creator><creator>Fornage, Myriam</creator><creator>Crawford, Dana C.</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20131201</creationdate><title>No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population</title><author>Dumitrescu, Logan ; Carty, Cara L. ; Franceschini, Nora ; Hindorff, Lucia A. ; Cole, Shelley A. ; Bůžková, Petra ; Schumacher, Fredrick R. ; Eaton, Charles B. ; Goodloe, Robert J. ; Duggan, David J. ; Haessler, Jeff ; Cochran, Barbara ; Henderson, Brian E. ; Cheng, Iona ; Johnson, Karen C. ; Carlson, Chris S. ; Love, Shelly-Anne ; Brown-Gentry, Kristin ; Nato, Alejandro Q. ; Quibrera, Miguel ; Shohet, Ralph V. ; Ambite, José Luis ; Wilkens, Lynne R. ; Le Marchand, Loïc ; Haiman, Christopher A. ; Buyske, Steven ; Kooperberg, Charles ; North, Kari E. ; Fornage, Myriam ; Crawford, Dana C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c571t-fc2f94a2410ee88421e04030da1a03c4f819df2bc904b98580d43effe2a496833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Analysis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer research</topic><topic>Cholesterol</topic><topic>Cholesterol, HDL - 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However, environmental modifiers, such as smoking, of these known genotype–phenotype associations are just recently emerging in the literature. We have tested for interactions between smoking and 49 GWAS-identified variants in over 41,000 racially/ethnically diverse samples with lipid levels from the Population Architecture Using Genomics and Epidemiology (PAGE) study. Despite their biological plausibility, we were unable to detect significant SNP × smoking interactions.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24100633</pmid><doi>10.1007/s00439-013-1375-3</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-6717 |
| ispartof | Human genetics, 2013-12, Vol.132 (12), p.1427-1431 |
| issn | 0340-6717 1432-1203 1432-1203 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3895337 |
| source | Springer Nature |
| subjects | Analysis Biomedical and Life Sciences Biomedicine Cancer research Cholesterol Cholesterol, HDL - metabolism Cholesterol, LDL - metabolism Cohort Studies Epidemiology Ethnicity - genetics Female Gene Frequency Gene Function Gene-Environment Interaction Genetic research Genetics Genetics, Population Genome-Wide Association Study - statistics & numerical data Genomes Genomics Health care High density lipoprotein Hispanic people Human Genetics Humans Lipid Metabolism - genetics Lipids Lipoproteins Low density lipoproteins Male Medical research Metabolic Diseases Molecular Medicine Polymorphism, Single Nucleotide Population Prevalence Preventive medicine Public health Short Report Smoking - epidemiology Smoking - ethnology Smoking - genetics Smoking - metabolism Triglycerides Triglycerides - metabolism Young Adult |
| title | No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T00%3A08%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=No%20evidence%20of%20interaction%20between%20known%20lipid-associated%20genetic%20variants%20and%20smoking%20in%20the%20multi-ethnic%20PAGE%20population&rft.jtitle=Human%20genetics&rft.au=Dumitrescu,%20Logan&rft.date=2013-12-01&rft.volume=132&rft.issue=12&rft.spage=1427&rft.epage=1431&rft.pages=1427-1431&rft.issn=0340-6717&rft.eissn=1432-1203&rft_id=info:doi/10.1007/s00439-013-1375-3&rft_dat=%3Cgale_pubme%3EA352753092%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c571t-fc2f94a2410ee88421e04030da1a03c4f819df2bc904b98580d43effe2a496833%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1449924464&rft_id=info:pmid/24100633&rft_galeid=A352753092&rfr_iscdi=true |