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Cancer Pharmacogenomics: Early Promise, But Concerted Effort Needed
The past decade has brought together substantial advances in human genome analysis and a maturation of understanding of tumor biology. Although there is much progress still to be made, there are now several prominent examples in which tumor-associated somatic mutations have been used to identify cel...
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Published in: | Science (American Association for the Advancement of Science) 2013-03, Vol.339 (6127), p.1563-1566 |
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description | The past decade has brought together substantial advances in human genome analysis and a maturation of understanding of tumor biology. Although there is much progress still to be made, there are now several prominent examples in which tumor-associated somatic mutations have been used to identify cellular signaling pathways in tumors. This in turn has led to the development of targeted therapies, with somatic mutations serving as genomic predictors of tumor response and providing new leads for drug development. There is also a realization that germline DNA variants can help optimize cancer drug dosing and predict the susceptibility of patients to the adverse side effects of these drugs—knowledge that ultimately can be used to improve the benefit:risk ratio of cancer treatment for individual patients. |
doi_str_mv | 10.1126/science.1234139 |
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drug therapy</subject><subject>Neoplasms - genetics</subject><subject>Oncology</subject><subject>Patients</subject><subject>Pharmaceutical sciences</subject><subject>Pharmacogenetics</subject><subject>REVIEWS</subject><subject>Sequencing</subject><subject>Side effects</subject><subject>Somatic mutation</subject><subject>Tumors</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkUtLxDAUhYMoOj7WrpSCGxd2zPvhQtAyPmBQF7oOaZpqh06jSSv4743MOKgbV0k43z3ckwPAPoJjhDA_jbZxnXVjhAlFRK2BEYKK5QpDsg5GEBKeSyjYFtiOcQZh0hTZBFuYMJKufASKwqT5kD28mDA31j-7zs8bG8-yiQntR_YQ0jO6k-xy6LPCf7G9q7JJXfvQZ3fOVa7aBRu1aaPbW5474Olq8ljc5NP769viYppbJlif1yU0UgrFWYkrwZUkllPJEWW2NsJQJCSGTAmOmKypLQ1XyhBccoFLqWpKdsD5wvd1KOeusq7rg2n1a2jmJnxobxr9W-maF_3s3zVRKTqWyeB4aRD82-Bir1M269rWdM4PUSMJJYICEvI_yjiXlCAFE3r0B535IXTpJzQiGFGaMJao0wVlg48xuHq1N4L6q0u97FIvu0wThz_jrvjv8hJwsABmsfdhpVOkKIYSk0-djqMU</recordid><startdate>20130329</startdate><enddate>20130329</enddate><creator>McLeod, Howard L.</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20130329</creationdate><title>Cancer Pharmacogenomics: Early Promise, But Concerted Effort Needed</title><author>McLeod, Howard L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c575t-fb0a887965b2d76983c6486145cfa7a4178205976158f4cba699a32b672b89f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Antineoplastic Agents - 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subjects | Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Biology Biomarkers, Pharmacological Biomarkers, Tumor - genetics Breast cancer Cancer Clinical trials DNA Dosing Drug Design Drugs Female Genetic Markers Genetic mutation Genome, Human Genomics Germ-Line Mutation Humans Molecular Targeted Therapy Mutations Neoplasms - drug therapy Neoplasms - genetics Oncology Patients Pharmaceutical sciences Pharmacogenetics REVIEWS Sequencing Side effects Somatic mutation Tumors |
title | Cancer Pharmacogenomics: Early Promise, But Concerted Effort Needed |
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