Going Mobile: AMPA Receptors Move Synapse to Synapse In Vivo

Plasticity models invoke the synaptic delivery of AMPARs, yet we know little about how receptors move in vivo. In this issue of Neuron, Hoerndli et al. (2013) show that lateral diffusion and kinesin-mediated transport move AMPARs between synapses in vivo.

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2013-12, Vol.80 (6), p.1339-1341
Main Author: Rongo, Christopher
Format: Article
Language:English
Subjects:
Animals
Behavior
Caenorhabditis elegans Proteins - metabolism
Caenorhabditis elegans Proteins - physiology
Cell Cycle Proteins - physiology
Hypotheses
Kinesin - physiology
Neurons
Receptors, AMPA - metabolism
Synaptic Transmission - physiology
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Description
Summary:Plasticity models invoke the synaptic delivery of AMPARs, yet we know little about how receptors move in vivo. In this issue of Neuron, Hoerndli et al. (2013) show that lateral diffusion and kinesin-mediated transport move AMPARs between synapses in vivo.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2013.11.031