Reduced protein C Global assay level in infertile women prior to IVF-ET treatment

Purpose In the last few years more robust evidence is emerging to point out at an increased rate of prematurity and low birth weight in singleton pregnancies following ART. Whether this increased rate is related to ART practice or to infertility per se, is still an open question. Our aim in this stu...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2014-01, Vol.31 (1), p.101-107
Main Authors: Younis, Johnny S., Ben-Ami, Moshe, Izhaki, Ido, Brenner, Benjamin, Sarig, Galit
Format: Article
Language:English
Subjects:
Adolescent
Adult
Assisted Reproduction Technologies
Birth weight
Blood Chemical Analysis - methods
Case-Control Studies
Cohort Studies
Embryo Transfer
Female
Fertility
Fertilization in Vitro
Gynecology
Hematology
Human Genetics
Humans
Infertility
Infertility, Female - blood
Infertility, Female - therapy
Medicine
Medicine & Public Health
Pregnancy
Pregnancy Rate
Protein C - analysis
Proteins
Reproductive Medicine
Reproductive technologies
Womens health
Young Adult
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Summary:Purpose In the last few years more robust evidence is emerging to point out at an increased rate of prematurity and low birth weight in singleton pregnancies following ART. Whether this increased rate is related to ART practice or to infertility per se, is still an open question. Our aim in this study was to explore this question by evaluating Protein C (ProC) Global assay in infertile women before ART treatment. Methods A cohort of 95 unselected and consecutive infertile women, eligible for ART, was prospectively recruited for the study. The control group included 77 matched healthy fertile women with a history of spontaneous conceptions. Pro C Global assay was evaluated in both groups. A full thrombophilic work-up was performed in the study group. Results ProC Global assay level was found to be significantly lower in the study as compared to the control group, corresponding to 0.78 ± 0.16 and 0.88 ± 0.16, respectively ( P  
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-013-0131-x