The Role of the Nucleus Accumbens Core in Impulsive Choice, Timing, and Reward Processing

• Published in: Behavioral neuroscience 2010-02, Vol.124 (1), p.26-43
• Main Authors: Galtress, Tiffany, Kirkpatrick, Kimberly
• Format: Article
• Language: English
• Subjects: Animal; Animals; Behavior; Behavior, Animal; Behavioral psychophysiology; Biological and medical sciences; Choice Behavior - physiology; Conditioning, Operant - physiology; Experimental psychology; Experiments; Fundamental and applied biological sciences. Psychology; Impulsive Behavior - physiopathology; Impulsiveness; Incentives; Information processing; Male; Models, Psychological; Nucleus Accumbens; Nucleus Accumbens - injuries; Nucleus Accumbens - physiology; Preferences; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rats; Reinforcement Delay; Reinforcement Schedule; Reward; Rewards; Rodents; Time Factors; Time Perception - physiology
• ISSN: 0735-7044; 1939-0084
• DOI: 10.1037/a0018464

The present series of experiments aimed to pinpoint the source of nucleus accumbens core (AcbC) effects on delay discounting. Rats were trained with an impulsive choice procedure between an adjusting smaller sooner reward and a fixed larger later reward. The AcbC-lesioned rats produced appropriate choice behavior when the reward magnitude was equal. An increase in reward magnitude resulted in a failure to increase preference for the larger later reward in the AcbC-lesioned rats, whereas a decrease in the larger later reward duration resulted in normal alterations in choice behavior in AcbC-lesioned rats. Subsequent experiments with a peak timing (Experiments 2 and 3) and a behavioral contrast (Experiment 4) indicated that the AcbC-lesioned rats suffered from decreased incentive motivation during changes in reward magnitude (Experiments 2 and 4) and when expected rewards were omitted (Experiments 2 and 3), but displayed intact anticipatory timing of reward delays (Experiments 2 and 3). The results indicate that the nucleus accumbens core is critical for determining the incentive value of rewards, but does not participate in the timing of reward delays.