Cardiomyocytes derived from human induced pluripotent stem cells as models for normal and diseased cardiac electrophysiology and contractility

Since the first description of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), these cells have garnered tremendous interest for their potential use in patient-specific analysis and therapy. Additionally, hiPSC-CMs can be derived from donor cells from patients with specific c...

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Bibliographic Details
Published in:Progress in biophysics and molecular biology 2012-10, Vol.110 (2-3), p.166-177
Main Authors: Blazeski, Adriana, Zhu, Renjun, Hunter, David W., Weinberg, Seth H., Zambidis, Elias T., Tung, Leslie
Format: Article
Language:English
Subjects:
Animals
Cardiac cell
Contraction
Electrophysiological Phenomena
Electrophysiology
Embryoid body
Heart - physiology
Heart - physiopathology
Heart Diseases - pathology
Heart Diseases - physiopathology
Human induced pluripotent stem cell
Humans
Induced Pluripotent Stem Cells - cytology
Induced Pluripotent Stem Cells - pathology
Lactic Acid
Myocardial Contraction
Myocytes, Cardiac - cytology
Myocytes, Cardiac - pathology
Optical mapping
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Summary:Since the first description of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), these cells have garnered tremendous interest for their potential use in patient-specific analysis and therapy. Additionally, hiPSC-CMs can be derived from donor cells from patients with specific cardiac disorders, enabling in vitro human disease models for mechanistic study and therapeutic drug assessment. However, a full understanding of their electrophysiological and contractile function is necessary before this potential can be realized. Here, we review this emerging field from a functional perspective, with particular emphasis on beating rate, action potential, ionic currents, multicellular conduction, calcium handling and contraction. We further review extant hiPSC-CM disease models that recapitulate genetic myocardial disease.
ISSN:0079-6107
1873-1732
DOI:10.1016/j.pbiomolbio.2012.07.013