Dual-phase cone-beam computed tomography to see, reach, and treat hepatocellular carcinoma during drug-eluting beads transarterial chemo-embolization

The advent of cone-beam computed tomography (CBCT) in the angiography suite has been revolutionary in interventional radiology. CBCT offers 3 dimensional (3D) diagnostic imaging in the interventional suite and can enhance minimally-invasive therapy beyond the limitations of 2D angiography alone. The...

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Bibliographic Details
Published in:Journal of visualized experiments 2013-12 (82), p.50795-50795
Main Authors: Tacher, Vania, Lin, Mingde, Bhagat, Nikhil, Abi Jaoudeh, Nadine, Radaelli, Alessandro, Noordhoek, Niels, Carelsen, Bart, Wood, Bradford J, Geschwind, Jean-François
Format: Article
Language:English
Subjects:
Angiography - instrumentation
Angiography - methods
Carcinoma, Hepatocellular - blood supply
Carcinoma, Hepatocellular - diagnostic imaging
Carcinoma, Hepatocellular - therapy
Chemoembolization, Therapeutic - methods
Cone-Beam Computed Tomography - methods
Doxorubicin - administration & dosage
Fluoroscopy - methods
Hepatic Artery - physiology
Humans
Liver Neoplasms - blood supply
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - therapy
Male
Medicine
Middle Aged
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Summary:The advent of cone-beam computed tomography (CBCT) in the angiography suite has been revolutionary in interventional radiology. CBCT offers 3 dimensional (3D) diagnostic imaging in the interventional suite and can enhance minimally-invasive therapy beyond the limitations of 2D angiography alone. The role of CBCT has been recognized in transarterial chemo-embolization (TACE) treatment of hepatocellular carcinoma (HCC). The recent introduction of a CBCT technique: dual-phase CBCT (DP-CBCT) improves intra-arterial HCC treatment with drug-eluting beads (DEB-TACE). DP-CBCT can be used to localize liver tumors with the diagnostic accuracy of multi-phasic multidetector computed tomography (M-MDCT) and contrast enhanced magnetic resonance imaging (CE-MRI) (See the tumor), to guide intra-arterially guidewire and microcatheter to the desired location for selective therapy (Reach the tumor), and to evaluate treatment success during the procedure (Treat the tumor). The purpose of this manuscript is to illustrate how DP-CBCT is used in DEB-TACE to see, reach, and treat HCC.
ISSN:1940-087X
1940-087X
DOI:10.3791/50795