The Burkholderia pseudomallei Enoyl-Acyl Carrier Protein Reductase FabI1 Is Essential for In Vivo Growth and Is the Target of a Novel Chemotherapeutic with Efficacy

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Published in:Antimicrobial Agents and Chemotherapy 2014-02, Vol.58 (2), p.931-935
Main Authors: CUMMINGS, Jason E, KINGRY, Luke C, RHOLL, Drew A, SCHWEIZER, Herbert P, TONGE, Peter J, SLAYDEN, Richard A
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial Proteins
Bacterial Proteins - antagonists & inhibitors
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Biological and medical sciences
Burkholderia pseudomallei
Burkholderia pseudomallei - drug effects
Burkholderia pseudomallei - enzymology
Burkholderia pseudomallei - genetics
Burkholderia pseudomallei - pathogenicity
Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific)
Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific) - antagonists & inhibitors
Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific) - genetics
Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific) - metabolism
Enzyme Inhibitors
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Experimental Therapeutics
Female
Gene Knockout Techniques
Isoenzymes - antagonists & inhibitors
Isoenzymes - genetics
Isoenzymes - metabolism
Medical sciences
Melioidosis
Melioidosis - drug therapy
Melioidosis - microbiology
Melioidosis - mortality
Mice
Mutation
Pharmacology. Drug treatments
Survival Analysis
Treatment Outcome
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Summary:Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AAC .asm.org, visit: AAC       
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00176-13