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Histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and alters HagB-induced chemokine responses
Histatins are human salivary gland peptides with anti-microbial and anti-inflammatory activities. In this study, we hypothesized that histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and attenuates HagB-induced chemokine responses in human myeloid dendritic cells. Histatin 5 bound...
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| Published in: | Scientific reports 2014-01, Vol.4 (1), p.3904-3904, Article 3904 |
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| creator | Borgwardt, Derek S. Martin, Aaron D. Van Hemert, Jonathan R. Yang, Jianyi Fischer, Carol L. Recker, Erica N. Nair, Prashant R. Vidva, Robinson Chandrashekaraiah, Shwetha Progulske-Fox, Ann Drake, David Cavanaugh, Joseph E. Vali, Shireen Zhang, Yang Brogden, Kim A. |
| description | Histatins are human salivary gland peptides with anti-microbial and anti-inflammatory activities. In this study, we hypothesized that histatin 5 binds to
Porphyromonas gingivalis
hemagglutinin B (HagB) and attenuates HagB-induced chemokine responses in human myeloid dendritic cells. Histatin 5 bound to immobilized HagB in a surface plasmon resonance (SPR) spectroscopy-based biosensor system. SPR spectroscopy kinetic and equilibrium analyses, protein microarray studies and I-TASSER structural modeling studies all demonstrated two histatin 5 binding sites on HagB. One site had a stronger affinity with a K
D1
of 1.9 μM and one site had a weaker affinity with a K
D2
of 60.0 μM. Binding has biological implications and predictive modeling studies and exposure of dendritic cells both demonstrated that 20.0 μM histatin 5 attenuated (p < 0.05) 0.02 μM HagB-induced CCL3/MIP-1α, CCL4/MIP-1β and TNFα responses. Thus histatin 5 is capable of attenuating chemokine responses, which may help control oral inflammation. |
| doi_str_mv | 10.1038/srep03904 |
| format | article |
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Porphyromonas gingivalis
hemagglutinin B (HagB) and attenuates HagB-induced chemokine responses in human myeloid dendritic cells. Histatin 5 bound to immobilized HagB in a surface plasmon resonance (SPR) spectroscopy-based biosensor system. SPR spectroscopy kinetic and equilibrium analyses, protein microarray studies and I-TASSER structural modeling studies all demonstrated two histatin 5 binding sites on HagB. One site had a stronger affinity with a K
D1
of 1.9 μM and one site had a weaker affinity with a K
D2
of 60.0 μM. Binding has biological implications and predictive modeling studies and exposure of dendritic cells both demonstrated that 20.0 μM histatin 5 attenuated (p < 0.05) 0.02 μM HagB-induced CCL3/MIP-1α, CCL4/MIP-1β and TNFα responses. Thus histatin 5 is capable of attenuating chemokine responses, which may help control oral inflammation.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep03904</identifier><identifier>PMID: 24473528</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/106 ; 13/21 ; 631/250 ; 631/250/127 ; 631/250/127/98 ; 82/103 ; 82/79 ; Adhesins, Bacterial - metabolism ; Affinity ; Bacterial Proteins - metabolism ; Binding Sites - physiology ; Biosensors ; CCL3 protein ; CCL4 protein ; Chemokines ; Chemokines - metabolism ; Dendritic cells ; Dendritic Cells - metabolism ; Hemagglutinins ; Hemoglobin ; Histatins - metabolism ; Humanities and Social Sciences ; Humans ; Inflammation ; Kinetics ; Lectins - metabolism ; multidisciplinary ; Myeloid Cells - metabolism ; Peptides ; Porphyromonas gingivalis - metabolism ; Protein arrays ; Protein Binding - physiology ; Salivary gland ; Science ; Spectroscopy ; Spectrum analysis ; Studies ; Surface plasmon resonance</subject><ispartof>Scientific reports, 2014-01, Vol.4 (1), p.3904-3904, Article 3904</ispartof><rights>The Author(s) 2014</rights><rights>Copyright Nature Publishing Group Jan 2014</rights><rights>Copyright © 2014, Macmillan Publishers Limited. All rights reserved 2014 Macmillan Publishers Limited. All rights reserved</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-3fdfebf0415f21cc39ac30a048a9d12e2704a4a9e976db63d160c3c8682508803</citedby><cites>FETCH-LOGICAL-c438t-3fdfebf0415f21cc39ac30a048a9d12e2704a4a9e976db63d160c3c8682508803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1897803512/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1897803512?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,25734,27905,27906,36993,36994,44571,53772,53774,74875</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24473528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Borgwardt, Derek S.</creatorcontrib><creatorcontrib>Martin, Aaron D.</creatorcontrib><creatorcontrib>Van Hemert, Jonathan R.</creatorcontrib><creatorcontrib>Yang, Jianyi</creatorcontrib><creatorcontrib>Fischer, Carol L.</creatorcontrib><creatorcontrib>Recker, Erica N.</creatorcontrib><creatorcontrib>Nair, Prashant R.</creatorcontrib><creatorcontrib>Vidva, Robinson</creatorcontrib><creatorcontrib>Chandrashekaraiah, Shwetha</creatorcontrib><creatorcontrib>Progulske-Fox, Ann</creatorcontrib><creatorcontrib>Drake, David</creatorcontrib><creatorcontrib>Cavanaugh, Joseph E.</creatorcontrib><creatorcontrib>Vali, Shireen</creatorcontrib><creatorcontrib>Zhang, Yang</creatorcontrib><creatorcontrib>Brogden, Kim A.</creatorcontrib><title>Histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and alters HagB-induced chemokine responses</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Histatins are human salivary gland peptides with anti-microbial and anti-inflammatory activities. In this study, we hypothesized that histatin 5 binds to
Porphyromonas gingivalis
hemagglutinin B (HagB) and attenuates HagB-induced chemokine responses in human myeloid dendritic cells. Histatin 5 bound to immobilized HagB in a surface plasmon resonance (SPR) spectroscopy-based biosensor system. SPR spectroscopy kinetic and equilibrium analyses, protein microarray studies and I-TASSER structural modeling studies all demonstrated two histatin 5 binding sites on HagB. One site had a stronger affinity with a K
D1
of 1.9 μM and one site had a weaker affinity with a K
D2
of 60.0 μM. Binding has biological implications and predictive modeling studies and exposure of dendritic cells both demonstrated that 20.0 μM histatin 5 attenuated (p < 0.05) 0.02 μM HagB-induced CCL3/MIP-1α, CCL4/MIP-1β and TNFα responses. Thus histatin 5 is capable of attenuating chemokine responses, which may help control oral inflammation.</description><subject>13/106</subject><subject>13/21</subject><subject>631/250</subject><subject>631/250/127</subject><subject>631/250/127/98</subject><subject>82/103</subject><subject>82/79</subject><subject>Adhesins, Bacterial - metabolism</subject><subject>Affinity</subject><subject>Bacterial Proteins - metabolism</subject><subject>Binding Sites - physiology</subject><subject>Biosensors</subject><subject>CCL3 protein</subject><subject>CCL4 protein</subject><subject>Chemokines</subject><subject>Chemokines - metabolism</subject><subject>Dendritic cells</subject><subject>Dendritic Cells - metabolism</subject><subject>Hemagglutinins</subject><subject>Hemoglobin</subject><subject>Histatins - metabolism</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Kinetics</subject><subject>Lectins - metabolism</subject><subject>multidisciplinary</subject><subject>Myeloid Cells - metabolism</subject><subject>Peptides</subject><subject>Porphyromonas gingivalis - metabolism</subject><subject>Protein arrays</subject><subject>Protein Binding - physiology</subject><subject>Salivary gland</subject><subject>Science</subject><subject>Spectroscopy</subject><subject>Spectrum analysis</subject><subject>Studies</subject><subject>Surface plasmon resonance</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNplkU9v1DAQxS0EolXpgS-ALHFpkQL-l419QaIVZZEqwQHO1qzjZF0SO3iSSv32eLXtagFfxvL8_PzGj5DXnL3nTOoPmP3EpGHqGTkVTNWVkEI8P9qfkHPEO1ZWLYzi5iU5EUo1shb6lKR1wBnmEGlNNyG2SOdEv6c8bR9yGlMEpH2IfbiHISDd-hH6flgKX25c0Ys19FeXFGJLYZh9Rro7qIrO4nxLXeHTrxA9zR6nFNHjK_KigwH9-WM9Iz9vPv-4Xle33758vf50Wzkl9VzJru38pmOK153gzkkDTjJgSoNpufCiYQoUGG-aVbtZyZavmJNOr7SomdZMnpGPe91p2Yy-dT7OGQY75TBCfrAJgv27E8PW9uneSsPL7-wELh4Fcvq9eJztGND5YYDo04KWKyMarhrDC_r2H_QuLTmW8SzXpiluai4KdbmnXE5YQusOZjizuyTtIcnCvjl2fyCfcivAuz2ApRV7n4-e_E_tD7UcqD8</recordid><startdate>20140129</startdate><enddate>20140129</enddate><creator>Borgwardt, Derek S.</creator><creator>Martin, Aaron D.</creator><creator>Van Hemert, Jonathan R.</creator><creator>Yang, Jianyi</creator><creator>Fischer, Carol L.</creator><creator>Recker, Erica N.</creator><creator>Nair, Prashant R.</creator><creator>Vidva, Robinson</creator><creator>Chandrashekaraiah, Shwetha</creator><creator>Progulske-Fox, Ann</creator><creator>Drake, David</creator><creator>Cavanaugh, Joseph E.</creator><creator>Vali, Shireen</creator><creator>Zhang, Yang</creator><creator>Brogden, Kim A.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140129</creationdate><title>Histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and alters HagB-induced chemokine responses</title><author>Borgwardt, Derek S. ; Martin, Aaron D. ; Van Hemert, Jonathan R. ; Yang, Jianyi ; Fischer, Carol L. ; Recker, Erica N. ; Nair, Prashant R. ; Vidva, Robinson ; Chandrashekaraiah, Shwetha ; Progulske-Fox, Ann ; Drake, David ; Cavanaugh, Joseph E. ; Vali, Shireen ; Zhang, Yang ; Brogden, Kim A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-3fdfebf0415f21cc39ac30a048a9d12e2704a4a9e976db63d160c3c8682508803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>13/106</topic><topic>13/21</topic><topic>631/250</topic><topic>631/250/127</topic><topic>631/250/127/98</topic><topic>82/103</topic><topic>82/79</topic><topic>Adhesins, Bacterial - metabolism</topic><topic>Affinity</topic><topic>Bacterial Proteins - metabolism</topic><topic>Binding Sites - physiology</topic><topic>Biosensors</topic><topic>CCL3 protein</topic><topic>CCL4 protein</topic><topic>Chemokines</topic><topic>Chemokines - metabolism</topic><topic>Dendritic cells</topic><topic>Dendritic Cells - metabolism</topic><topic>Hemagglutinins</topic><topic>Hemoglobin</topic><topic>Histatins - metabolism</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Kinetics</topic><topic>Lectins - metabolism</topic><topic>multidisciplinary</topic><topic>Myeloid Cells - metabolism</topic><topic>Peptides</topic><topic>Porphyromonas gingivalis - metabolism</topic><topic>Protein arrays</topic><topic>Protein Binding - physiology</topic><topic>Salivary gland</topic><topic>Science</topic><topic>Spectroscopy</topic><topic>Spectrum analysis</topic><topic>Studies</topic><topic>Surface plasmon resonance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Borgwardt, Derek S.</creatorcontrib><creatorcontrib>Martin, Aaron D.</creatorcontrib><creatorcontrib>Van Hemert, Jonathan R.</creatorcontrib><creatorcontrib>Yang, Jianyi</creatorcontrib><creatorcontrib>Fischer, Carol L.</creatorcontrib><creatorcontrib>Recker, Erica N.</creatorcontrib><creatorcontrib>Nair, Prashant R.</creatorcontrib><creatorcontrib>Vidva, Robinson</creatorcontrib><creatorcontrib>Chandrashekaraiah, Shwetha</creatorcontrib><creatorcontrib>Progulske-Fox, Ann</creatorcontrib><creatorcontrib>Drake, David</creatorcontrib><creatorcontrib>Cavanaugh, Joseph E.</creatorcontrib><creatorcontrib>Vali, Shireen</creatorcontrib><creatorcontrib>Zhang, Yang</creatorcontrib><creatorcontrib>Brogden, Kim A.</creatorcontrib><collection>SpringerOpen(OpenAccess)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Journals</collection><collection>Biological Science Database</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Borgwardt, Derek S.</au><au>Martin, Aaron D.</au><au>Van Hemert, Jonathan R.</au><au>Yang, Jianyi</au><au>Fischer, Carol L.</au><au>Recker, Erica N.</au><au>Nair, Prashant R.</au><au>Vidva, Robinson</au><au>Chandrashekaraiah, Shwetha</au><au>Progulske-Fox, Ann</au><au>Drake, David</au><au>Cavanaugh, Joseph E.</au><au>Vali, Shireen</au><au>Zhang, Yang</au><au>Brogden, Kim A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and alters HagB-induced chemokine responses</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2014-01-29</date><risdate>2014</risdate><volume>4</volume><issue>1</issue><spage>3904</spage><epage>3904</epage><pages>3904-3904</pages><artnum>3904</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Histatins are human salivary gland peptides with anti-microbial and anti-inflammatory activities. In this study, we hypothesized that histatin 5 binds to
Porphyromonas gingivalis
hemagglutinin B (HagB) and attenuates HagB-induced chemokine responses in human myeloid dendritic cells. Histatin 5 bound to immobilized HagB in a surface plasmon resonance (SPR) spectroscopy-based biosensor system. SPR spectroscopy kinetic and equilibrium analyses, protein microarray studies and I-TASSER structural modeling studies all demonstrated two histatin 5 binding sites on HagB. One site had a stronger affinity with a K
D1
of 1.9 μM and one site had a weaker affinity with a K
D2
of 60.0 μM. Binding has biological implications and predictive modeling studies and exposure of dendritic cells both demonstrated that 20.0 μM histatin 5 attenuated (p < 0.05) 0.02 μM HagB-induced CCL3/MIP-1α, CCL4/MIP-1β and TNFα responses. Thus histatin 5 is capable of attenuating chemokine responses, which may help control oral inflammation.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>24473528</pmid><doi>10.1038/srep03904</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Scientific reports, 2014-01, Vol.4 (1), p.3904-3904, Article 3904 |
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| language | eng |
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| source | Publicly Available Content (ProQuest); PubMed Central; Free Full-Text Journals in Chemistry; Springer Nature - nature.com Journals - Fully Open Access |
| subjects | 13/106 13/21 631/250 631/250/127 631/250/127/98 82/103 82/79 Adhesins, Bacterial - metabolism Affinity Bacterial Proteins - metabolism Binding Sites - physiology Biosensors CCL3 protein CCL4 protein Chemokines Chemokines - metabolism Dendritic cells Dendritic Cells - metabolism Hemagglutinins Hemoglobin Histatins - metabolism Humanities and Social Sciences Humans Inflammation Kinetics Lectins - metabolism multidisciplinary Myeloid Cells - metabolism Peptides Porphyromonas gingivalis - metabolism Protein arrays Protein Binding - physiology Salivary gland Science Spectroscopy Spectrum analysis Studies Surface plasmon resonance |
| title | Histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and alters HagB-induced chemokine responses |
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