D1-dopamine and α1-adrenergic receptors co-localize in dendrites of the rat prefrontal cortex

Highlights • D1 dopamine and α1-adrenergic receptors co-localize in prefrontal cortex neurons. • Amount of co-localization is greatest in dendrites. • A greater fraction of α1-adrenergic receptors are intracellular in D1R co-expressing dendrites. • Identical results were found for the α1b-adrenergic...

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Bibliographic Details
Published in:Neuroscience 2014-01, Vol.258, p.90-100
Main Authors: Mitrano, D.A, Pare, J.-F, Smith, Y, Weinshenker, D
Format: Article
Language:English
Subjects:
Animals
Axons - metabolism
Axons - ultrastructure
Biological and medical sciences
catecholamine
Cell Membrane - metabolism
Cell Membrane - ultrastructure
D1 dopamine receptor
Dendrites - metabolism
Dendrites - ultrastructure
Dendritic Spines - metabolism
Dendritic Spines - ultrastructure
electron microscopy
Fundamental and applied biological sciences. Psychology
Immunohistochemistry
Male
Microscopy, Electron
Nerve Fibers, Unmyelinated - metabolism
Nerve Fibers, Unmyelinated - ultrastructure
Neurology
Neurons - metabolism
Neurons - ultrastructure
prefrontal cortex
Prefrontal Cortex - metabolism
Prefrontal Cortex - ultrastructure
Rats
Rats, Sprague-Dawley
Receptors, Adrenergic, alpha-1 - metabolism
Receptors, Dopamine D1 - metabolism
Synapses - metabolism
Synapses - ultrastructure
Vertebrates: nervous system and sense organs
α1-adrenergic receptor
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Summary:Highlights • D1 dopamine and α1-adrenergic receptors co-localize in prefrontal cortex neurons. • Amount of co-localization is greatest in dendrites. • A greater fraction of α1-adrenergic receptors are intracellular in D1R co-expressing dendrites. • Identical results were found for the α1b-adrenergic subtype.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.11.002