Magnetic Resonance-Guided Laser Induced Thermal Therapy for Glioblastoma Multiforme : A Review

Magnetic resonance-guided laser induced thermotherapy (MRgLITT) has become an increasingly relevant therapy for tumor ablation due to its minimally invasive approach and broad applicability across many tissue types. The current state of the art applies laser irradiation via cooled optical fiber appl...

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Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-9
Main Authors: Norred, Sarah E., Johnson, Jacqueline Anne
Format: Article
Language:English
Subjects:
Brain cancer
Brain Neoplasms - therapy
Cancer therapies
Care and treatment
Glioblastoma - therapy
Glioblastoma multiforme
Humans
Hyperthermia, Induced - instrumentation
Hyperthermia, Induced - methods
Laser therapy
Lasers
Magnetic resonance imaging
Magnetic Resonance Imaging - instrumentation
Magnetic Resonance Imaging - methods
Methods
NMR
Nuclear magnetic resonance
Review
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Summary:Magnetic resonance-guided laser induced thermotherapy (MRgLITT) has become an increasingly relevant therapy for tumor ablation due to its minimally invasive approach and broad applicability across many tissue types. The current state of the art applies laser irradiation via cooled optical fiber applicators in order to generate ablative heat and necrosis in tumor tissue. Magnetic resonance temperature imaging (MRTI) is used concurrently with this therapy to plan treatments and visualize tumor necrosis. Though application in neurosurgery remains in its infancy, MRgLITT has been found to be a promising therapy for many types of brain tumors. This review examines the current use of MRgLITT with regard to the special clinical challenge of glioblastoma multiforme and examines the potential applications of next-generation nanotherapy specific to the treatment of glioblastoma.
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/761312