Association of genetic polymorphism of HLA-DRB1 antigens with the susceptibility to lepromatous leprosy

Despite the introduction of multidrug therapy and the overall reduction of leprosy prevalence in Mexico, the disease remains endemic in certain regions of the country. A genetic basis for the immune susceptibility to Mycobacterium leprae has already been established in different populations worldwid...

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Bibliographic Details
Published in:Biomedical reports 2013-11, Vol.1 (6), p.945-949
Main Authors: ESCAMILLA-TILCH, MONICA, TORRES-CARRILLO, NORA MAGDALENA, PAYAN, ROSALIO RAMOS, AGUILAR-MEDINA, MARIBEL, SALAZAR, MA ISABEL, FAFUTIS-MORRIS, MARY, ARENAS-GUZMAN, ROBERTO, ESTRADA-PARRA, SERGIO, ESTRADA-GARCIA, IRIS, GRANADOS, JULIO
Format: Article
Language:English
Subjects:
Alleles
Antigens
Confidence intervals
Disease
Drb1 protein
Females
Gene polymorphism
Genes
Genetic aspects
Genetic polymorphisms
Genetic susceptibility
Genomes
Health aspects
Health care
Histocompatibility antigen HLA
HLA antigens
HLA-DRB1
Infections
Leprosy
Medical research
Pathogenesis
Polymorphism
Population genetics
Population studies
Populations
Risk factors
Software
Studies
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Summary:Despite the introduction of multidrug therapy and the overall reduction of leprosy prevalence in Mexico, the disease remains endemic in certain regions of the country. A genetic basis for the immune susceptibility to Mycobacterium leprae has already been established in different populations worldwide. In this study, we investigated the possible association of the HLA-DRB1 alleles with leprosy in a Mexican Mestizo population. The results demonstrated that the HLA-DRB1*01 allele is associated with lepromatous and dimorphic leprosy [P
ISSN:2049-9434
2049-9442
DOI:10.3892/br.2013.167