A potential pathogenetic role of iron in Alzheimer's disease

The role of iron in the pathogenesis of Alzheimer's disease (AD) is still unclear, despite the evidence that it accumulates in the same brain regions characterized by the amyloid β peptide (Aβ) accumulation. Here we propose that iron directly influences the Aβ production through the modulation...

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Bibliographic Details
Published in:Journal of cellular and molecular medicine 2008-09, Vol.12 (5a), p.1548-1550
Main Authors: Silvestri, Laura, Camaschella, Clara
Format: Article
Language:English
Subjects:
Alzheimer Disease - genetics
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Alzheimer's disease
Amyloid beta-Peptides - metabolism
Animals
furin
Genetics
Humans
Iron
Iron - metabolism
Medical Hypothesis
Peptides
Proteins
Signal Transduction
Up-Regulation
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Summary:The role of iron in the pathogenesis of Alzheimer's disease (AD) is still unclear, despite the evidence that it accumulates in the same brain regions characterized by the amyloid β peptide (Aβ) accumulation. Here we propose that iron directly influences the Aβ production through the modulation of furin, a proconvertase involved in the regulation of the α‐secretase‐dependent processing of the amyloid protein precursor (APP).
ISSN:1582-1838
1582-4934
DOI:10.1111/j.1582-4934.2008.00356.x