Long-Acting Delivery Systems for Peptides: Inhibition of Rat Prostate Tumors by Controlled Release of [D-Trp6]luteinizing Hormone-Releasing Hormone from Injectable Microcapsules

Intramuscular injection of [6-D-tryptophan]-luteinizing hormone-releasing hormone ([D-Trp6]LH-RH) in microcapsules of poly(DL-lactide-co-glycolide), designed to release a controlled dose of the peptide over a 30-day period, decreased the weights of androgen-dependent Dunning prostate tumors in rats...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1984-09, Vol.81 (18), p.5845-5848
Main Authors: Redding, Tommie W., Schally, Andrew V., Tice, Thomas R., Meyers, William E.
Format: Article
Language:English
Subjects:
Animals
Blood
Capsules
Cell Line
Delayed-Action Preparations
Gonadotropin-Releasing Hormone - administration & dosage
Gonadotropin-Releasing Hormone - analogs & derivatives
Gonadotropin-Releasing Hormone - therapeutic use
Hormones
Intravenous injections
Luteinization
Luteolytic Agents - therapeutic use
Male
Microscopy, Electron, Scanning
Prostate
Prostate cancer
Prostatic Neoplasms - drug therapy
Rats
Rats, Inbred Strains
Testosterone
Triptorelin Pamoate
Tumor burden
Tumors
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Summary:Intramuscular injection of [6-D-tryptophan]-luteinizing hormone-releasing hormone ([D-Trp6]LH-RH) in microcapsules of poly(DL-lactide-co-glycolide), designed to release a controlled dose of the peptide over a 30-day period, decreased the weights of androgen-dependent Dunning prostate tumors in rats and suppressed serum testosterone levels more effectively than daily subcutaneous administration of equivalent or double doses of unencapsulated [D-Trp6]LH-RH. The microcapsules or daily injections of [D-Trp6]LH-RH also significantly decreased tumor volumes. Microcapsules of [D-Trp6]LH-RH or related analogs that can be injected once a month should make the treatment of patients with prostate carcinoma and other neoplasms or disorders more convenient and efficacious.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.81.18.5845