Study on antiphospholipid / anticardioliplin antibodies in women with recurrent abortion

• Published in: Iranian red crescent medical journal 2013-08, Vol.15 (8), p.718-722
• Main Authors: Akhlaghi, Faridah, Tafazoli, Mehri, Keramati, Muhammad Rida
• Format: Article
• Language: English
• Subjects: Abortion; Autoantibodies; Complications; Etiology; Pregnancy; الأمراض; الإجهاض; الحمل; المرأة الحامل; المناعة الذاتية; علم الأمراض; مسببات الأمراض
• ISSN: 2074-1804; 2074-1812
• DOI: 10.5812/ircmj.4857

Background : Antiphospholipid antibodies are associated with recurrent abortion but correlation between level of antibodies and gestational age of abortion and duration post abortion is not clear. Objectives : Aim of this study was study on relation between ant phospholipid antibodies in women with recurrent abortion and their gestational age and duration post abortion. Patients and Methods : We performed a case-control study on 197 pregnant women who had history of spontaneous recurrent abortion as case group and 50 pregnant healthy women as control group. Demographic characteristic of all participants filled in questionnaire forms. Antipospholipid and anticardiolipin antibodies were measured in their serum by Enzyme linked Immunoassay with orgenec kits. Data analyzed by SPSS software (version 13) and T statistical test. P value less than 0.05 was considered significant. Results : Mean age of participants was 24-39 years old. The average rate of antiphospolipid antibodies in patients with normal anticardiolipin was greater than those with abnormal anticardiolipin and T-test showed significant difference between two groups. (P = 0.000) In case group the number of abortions was more, mean of antiphosopolipid antibody levels were also higher. Mean anticardiolipin and antiphospholipid antibodies rate was greater with increasing gestational age at time of first abortion. Almost mean antipospholipid and anticardiolipin antibodies in all patients remained in high level just in first 5 years with any number of abortions and five years later, antibodies began to fall. Conclusions : Antipospholipid antibodies based on number of abortions and gestational age of abortions were increased. Mean antipospholipid and anticardiolipin antibodies in all patients remained in high level just in first 5 years post abortion and then began to fall.