Comparative absorption of curcumin formulations

BACKGROUND: The potential health benefits of curcumin are limited by its poor solubility, low absorption from the gut, rapid metabolism and rapid systemic elimination. The purpose of this study was the comparative measurement of the increases in levels of curcuminoids (curcumin, demethoxycurcumin, b...

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Bibliographic Details
Published in:Nutrition journal 2014-01, Vol.13 (1), p.11-11, Article 11
Main Authors: Jäger, Ralf, Lowery, Ryan P, Calvanese, Allison V, Joy, Jordan M, Purpura, Martin, Wilson, Jacob M
Format: Article
Language:English
Subjects:
absorption
Administration, Oral
Adult
antioxidants
Aqueous solutions
blood
Cell cycle
Cellulose
Colleges & universities
Comparative analysis
curcumin
Curcumin - administration & dosage
Curcumin - analogs & derivatives
Diarylheptanoids
digestive system
Enzymes
Female
Health aspects
Health insurance
Humans
intestinal absorption
Intestinal Absorption - physiology
Male
Measurement
metabolism
Metabolites
Methods
Nanocrystals
oils
oral administration
Physical fitness
Plasma
Solubility
Surfactants
turmeric
volunteers
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Summary:BACKGROUND: The potential health benefits of curcumin are limited by its poor solubility, low absorption from the gut, rapid metabolism and rapid systemic elimination. The purpose of this study was the comparative measurement of the increases in levels of curcuminoids (curcumin, demethoxycurcumin, bisdemethoxycurcumin) and the metabolite tetrahydrocurcumin after oral administration of three different curcumin formulations in comparison to unformulated standard. METHODS: The relative absorption of a curcumin phytosome formulation (CP), a formulation with volatile oils of turmeric rhizome (CTR) and a formulation of curcumin with a combination of hydrophilic carrier, cellulosic derivatives and natural antioxidants (CHC) in comparison to a standardized curcumin mixture (CS) was investigated in a randomized, double-blind, crossover human study in healthy volunteers. Samples were analyzed by HPLC-MS/MS. RESULTS: Total curcuminoids appearance in the blood was 1.3-fold higher for CTR and 7.9-fold higher for CP in comparison to unformulated CS. CHC showed a 45.9-fold higher absorption over CS and significantly improved absorption over CP (5.8-fold) and CTR (34.9-fold, all p 
ISSN:1475-2891
1475-2891
DOI:10.1186/1475-2891-13-11