Clinical significance of P-glycoprotein and glutathione S-transferase π expression in gallbladder carcinoma

P-glycoprotein (P-gp) and glutathione S-transferase π (GST-π) are not only drug-resistance markers, but also prognostic markers of various cancers. The aim of the present study was to investigate the clinical significance of P-gp and GST-π in gallbladder carcinoma (GBC). Tissue samples from 42 patie...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2014-03, Vol.7 (3), p.635-639
Main Authors: MA, QING-JIU, ZHANG, YU-CUN, SHI, JING-SEN, LI, GUO-CAI
Format: Article
Language:English
Subjects:
Age
Antigens
Cancer
Carcinogens
Care and treatment
Clinical significance
Drug resistance
Females
Gallbladder
Gallbladder cancer
Gallbladder diseases
Gallstones
Gender
Genetic aspects
glutathione S-transferase
Glutathione transferase
Glycoproteins
Medical prognosis
Metabolism
Metastasis
Multivariate analysis
P-glycoprotein
Pathology
Patients
Physiological aspects
prognosis
Risk factors
Rodents
Statistical analysis
Citations: Items that this one cites
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Summary:P-glycoprotein (P-gp) and glutathione S-transferase π (GST-π) are not only drug-resistance markers, but also prognostic markers of various cancers. The aim of the present study was to investigate the clinical significance of P-gp and GST-π in gallbladder carcinoma (GBC). Tissue samples from 42 patients with GBC were immunostained. Demographic, clinical and follow-up data were collected and analyzed. The positive expression rates of P-gp and GST-π in the GBC tissues were significantly higher (76.2 and 64.3%, respectively) than that of chronic cholecystitis specimens (30 and 20%, respectively) (P=0.014 and 0.035, respectively), and correlated with the Nevin stage of GBC. Multivariate analysis demonstrated that patients with positive expression of P-gp and GST-π showed a significantly lower 2-year survival rate (11.1 and 12%, respectively) compared with patients with negative expression (55.6 and 45.5%, respectively) (P=0.013 and 0.036, respectively). P-gp was also found to be an independent prognostic marker of 2-year survival rate by logistic regression analysis (B=−2.76, P=0.061). Results of this study suggest that P-gp is a prognostic marker of GBC and the detection of P-gp and GST-π may contribute to the prognosis of GBC and the application of chemotherapy as a therapeutic treatment.
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2014.1472