Clinical significance of P-glycoprotein and glutathione S-transferase π expression in gallbladder carcinoma

• Published in: Experimental and therapeutic medicine 2014-03, Vol.7 (3), p.635-639
• Main Authors: MA, QING-JIU, ZHANG, YU-CUN, SHI, JING-SEN, LI, GUO-CAI
• Format: Article
• Language: English
• Subjects: Age; Antigens; Cancer; Carcinogens; Care and treatment; Clinical significance; Drug resistance; Females; Gallbladder; Gallbladder cancer; Gallbladder diseases; Gallstones; Gender; Genetic aspects; glutathione S-transferase; Glutathione transferase; Glycoproteins; Medical prognosis; Metabolism; Metastasis; Multivariate analysis; P-glycoprotein; Pathology; Patients; Physiological aspects; prognosis; Risk factors; Rodents; Statistical analysis
• ISSN: 1792-0981; 1792-1015
• DOI: 10.3892/etm.2014.1472

P-glycoprotein (P-gp) and glutathione S-transferase π (GST-π) are not only drug-resistance markers, but also prognostic markers of various cancers. The aim of the present study was to investigate the clinical significance of P-gp and GST-π in gallbladder carcinoma (GBC). Tissue samples from 42 patients with GBC were immunostained. Demographic, clinical and follow-up data were collected and analyzed. The positive expression rates of P-gp and GST-π in the GBC tissues were significantly higher (76.2 and 64.3%, respectively) than that of chronic cholecystitis specimens (30 and 20%, respectively) (P=0.014 and 0.035, respectively), and correlated with the Nevin stage of GBC. Multivariate analysis demonstrated that patients with positive expression of P-gp and GST-π showed a significantly lower 2-year survival rate (11.1 and 12%, respectively) compared with patients with negative expression (55.6 and 45.5%, respectively) (P=0.013 and 0.036, respectively). P-gp was also found to be an independent prognostic marker of 2-year survival rate by logistic regression analysis (B=−2.76, P=0.061). Results of this study suggest that P-gp is a prognostic marker of GBC and the detection of P-gp and GST-π may contribute to the prognosis of GBC and the application of chemotherapy as a therapeutic treatment.