Relationship of Podoplanin and Glutathione S-transferases T1 Expression with Laryngeal Cancer

The aim of this study is to determine whether there is a role of podoplanin and glutathione S-transferases T1 (GST-T1) expression in laryngeal squamous cell carcinoma. The study was completed with 33 patients and gene expression analysis was performed by qRT-PCR. The podoplanin and GST-T1 expression...

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Published in:International journal of molecular and cellular medicine 2012-01, Vol.1 (4), p.217-224
Main Authors: Kanliada, Deniz, Coskunpinar, Ender, Serkan Orhan, Kadir, Musteri Oltulu, Yasemin, Celik, Mehmet, Eren, Ayse, Yaylim, Ilhan, Deger, Kemal
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container_issue 4
container_start_page 217
container_title International journal of molecular and cellular medicine
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creator Kanliada, Deniz
Coskunpinar, Ender
Serkan Orhan, Kadir
Musteri Oltulu, Yasemin
Celik, Mehmet
Eren, Ayse
Yaylim, Ilhan
Deger, Kemal
description The aim of this study is to determine whether there is a role of podoplanin and glutathione S-transferases T1 (GST-T1) expression in laryngeal squamous cell carcinoma. The study was completed with 33 patients and gene expression analysis was performed by qRT-PCR. The podoplanin and GST-T1 expression patterns were analyzed to determine their correlation with clinicopathologic parameters of laryngeal cancer. Of all patients, 20 had supraglottic, and the remaining 13 had glottic laryngeal cancer. Increased expression of podoplanin was found in 14 tumor tissues, but GST-T1 expression was not detected. Podoplanin expression did not show any prediction for regional metastasis, thyroid cartilage invasion, lymphatic vessel invasion or tumor differentiation for laryngeal cancer, also there were no significant differences in podoplanin expression between glottic and supraglottic regions, but extracapsullar extension is almost statistically significant (p=0,05).
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title Relationship of Podoplanin and Glutathione S-transferases T1 Expression with Laryngeal Cancer
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