Sustained release of naproxen in a new kind delivery system of carbon nanotubes hydrogel

In this paper, carbon nanotubes (CNTs) were added into chitosan (CS) hydrogels in the form of chitosan modified CNTs (CS-CNTs) composites to prepare carbon nanotubes hydrogels (CNTs-GEL). The products, named CS-MWCNTs, were characterized by scanning electron microscope (SEM) and Fourier transform in...

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Bibliographic Details
Published in:Iranian journal of pharmaceutical research : IJPR 2013, Vol.12 (4), p.581-586
Main Authors: Peng, Xiahui, Zhuang, Qiang, Peng, Dongming, Dong, Qiuli, Tan, Lini, Jiao, Feipeng, Liu, Linqi, Liu, Jingyu, Zhao, Chenxi, Wang, Xiaomei
Format: Article
Language:English
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Summary:In this paper, carbon nanotubes (CNTs) were added into chitosan (CS) hydrogels in the form of chitosan modified CNTs (CS-CNTs) composites to prepare carbon nanotubes hydrogels (CNTs-GEL). The products, named CS-MWCNTs, were characterized by scanning electron microscope (SEM) and Fourier transform infrared (FTIR) spectroscopy. Swelling properties and effect of pH on controlled release performance of the two kinds of hydrogels, CNTs- GEL and pure chitosan hydrogels without CNTs (GEL), were investigated respectively. The results showed that CNTs-GEL possess better controlled release performance than GEL. The releasing equilibrium time of CNTs-GEL was longer than that of GEL in both pH = w7.4 and pH=1.2 conditions, although the release ratios of the model drug are similar in the same pH buffer solutions. It is found that release kinetics is better fitted Ritger-Peppas empirical model indicating a fick-diffusion process in pH = 1.2, while in pH = 7.4 it was non-fick diffusion involving surface diffusion and corrosion diffusion processes.
ISSN:1735-0328
1726-6890