The neural basis of temporal individuation and its capacity limits in the human brain

• Published in: Journal of neurophysiology 2014-02, Vol.111 (3), p.499-512
• Main Authors: Naughtin, Claire K, Tamber-Rosenau, Benjamin J, Dux, Paul E
• Format: Article
• Language: English
• Subjects: Adult; Brain - physiology; Brain Mapping; Evoked Potentials, Visual; Female; Humans; Magnetic Resonance Imaging; Male; Reaction Time; Visual Perception
• ISSN: 0022-3077; 1522-1598
• DOI: 10.1152/jn.00534.2013

Individuation refers to individuals' use of spatial and temporal properties to register an object as a distinct perceptual event relative to other stimuli. Although behavioral studies have examined both spatial and temporal individuation, neuroimaging investigations of individuation have been restricted to the spatial domain and at relatively late stages of information processing. In this study we used univariate and multivoxel pattern analyses of functional magnetic resonance imaging data to identify brain regions involved in individuating temporally distinct visual items and the neural consequences that arise when this process reaches its capacity limit (repetition blindness, RB). First, we found that regional patterns of blood oxygen level-dependent activity in a large group of brain regions involved in "lower-level" perceptual and "higher-level" attentional/executive processing discriminated between instances where repeated and nonrepeated stimuli were successfully individuated, conditions that placed differential demands on temporal individuation. These results could not be attributed to repetition suppression, stimulus or response factors, task difficulty, regional activation differences, other capacity-limited processes, or artifacts in the data or analyses. Consistent with the global workplace model of consciousness, this finding suggests that temporal individuation is supported by a distributed set of brain regions, rather than a single neural correlate. Second, conditions that reflect the capacity limit of individuation (instances of RB) modulated the amplitude, rather than spatial pattern, of activity in the left hemisphere premotor cortex. This finding could not be attributed to response conflict/ambiguity and likely reflects a candidate brain region underlying the capacity-limited process that gives rise to RB.