Genetics of hypertension: discoveries from the bench to human populations

Hypertension is a complex trait that is influenced by both heritable and environmental factors. The search for genes accounting for the susceptibility to hypertension has driven parallel efforts in human research and in research using experimental animals in controlled environmental settings. Eviden...

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Bibliographic Details
Published in:American journal of physiology. Renal physiology 2014-01, Vol.306 (1), p.F1-F11
Main Authors: Franceschini, Nora, Le, Thu H
Format: Article
Language:English
Subjects:
Animals
Blood Pressure - physiology
Genetic Predisposition to Disease
Genomics
Homeostasis
Humans
Hypertension
Hypertension - genetics
Kidneys
Reviews
Sodium
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Summary:Hypertension is a complex trait that is influenced by both heritable and environmental factors. The search for genes accounting for the susceptibility to hypertension has driven parallel efforts in human research and in research using experimental animals in controlled environmental settings. Evidence from rodent models of genetic hypertension and human Mendelian forms of hypertension and hypotension have yielded mechanistic insights into the pathways that are perturbed in blood pressure homeostasis, most of which converge at the level of renal sodium reabsorption. However, the bridging of evidence from these very diverse approaches to identify mechanisms underlying hypertension susceptibility and the translation of these findings to human populations and public health remain a challenge. Furthermore, findings from genome-wide association studies still require functional validation in experimental models. In this review, we highlight results and implications from key studies in experimental and clinical hypertension to date.
ISSN:1931-857X
1522-1466
DOI:10.1152/ajprenal.00334.2013