Protein folding and de novo protein design for biotechnological applications

Highlights • Interplay between accurate protein structure prediction and successful de novo protein design. • Reviews current state-of-the-art structural protein prediction methods and challenges. • Reviews features of successful de novo protein designs. • Biotechnology applications in therapeutics,...

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2014-02, Vol.32 (2), p.99-109
Main Authors: Khoury, George A, Smadbeck, James, Kieslich, Chris A, Floudas, Christodoulos A
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biotechnology
Biotechnology - methods
computational biology
Computational Biology - methods
de novo protein design
Fundamental and applied biological sciences. Psychology
Internal Medicine
Molecular Dynamics Simulation
Protein Engineering - methods
Protein Folding
protein structure prediction
Recombinant Proteins - isolation & purification
Recombinant Proteins - metabolism
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Summary:Highlights • Interplay between accurate protein structure prediction and successful de novo protein design. • Reviews current state-of-the-art structural protein prediction methods and challenges. • Reviews features of successful de novo protein designs. • Biotechnology applications in therapeutics, biocatalysts, and nanomaterials are summarized.
ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2013.10.008