A comparison of liver protection among 3-D conformal radiotherapy, intensity-modulated radiotherapy and RapidArc for hepatocellular carcinoma

The analysis was designed to compare dosimetric parameters among 3-D conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT) and RapidArc (RA) to identify which can achieve the lowest risk of radiation-induced liver disease (RILD) for hepatocellular carcinoma (HCC). Twenty patients w...

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Bibliographic Details
Published in:Radiation oncology (London, England) England), 2014-02, Vol.9 (1), p.48-48, Article 48
Main Authors: Chen, Dong, Wang, Renben, Meng, Xiangjiao, Liu, Tonghai, Yan, Hongjiang, Feng, Rui, Liu, Shangang, Jiang, Shumei, Xu, Xiaoqing, Zhu, Kunli, Dou, Xue
Format: Article
Language:English
Subjects:
Adult
Aged
Cancer therapies
Carcinoma, Hepatocellular - radiotherapy
Care and treatment
Comparative analysis
Diagnosis
Female
Health aspects
Hepatitis
Hepatoma
Hospitals
Humans
Kidneys
Liver - pathology
Liver - radiation effects
Liver cancer
Liver cirrhosis
Liver diseases
Liver Neoplasms - radiotherapy
Male
Middle Aged
Organ Sparing Treatments - methods
Organs at Risk
Radiation
Radiation therapy
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted - standards
Radiotherapy, Conformal - adverse effects
Radiotherapy, Conformal - methods
Radiotherapy, Image-Guided - methods
Radiotherapy, Intensity-Modulated - adverse effects
Retrospective Studies
Spinal cord
Tomography
Tumors
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Summary:The analysis was designed to compare dosimetric parameters among 3-D conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT) and RapidArc (RA) to identify which can achieve the lowest risk of radiation-induced liver disease (RILD) for hepatocellular carcinoma (HCC). Twenty patients with HCC were enrolled in this study. Dosimetric values for 3DCRT, IMRT, and RA were calculated for total dose of 50 Gy/25 f. The percentage of the normal liver volume receiving >40, >30, >20, >10, and >5 Gy (V(40), V(30), V(20), V(10) and V(5)) were evaluated to determine liver toxicity. V5, V(10), V(20), V(30) and D(mean) of liver were compared as predicting parameters for RILD. Other parameters included the conformal index (CI), homogeneity index (HI), and hot spot (V(110%)) for the planned target volume (PTV) as well as the monitor units (MUs) for plan efficiency, the mean dose (D(mean)) for the organs at risk (OARs) and the maximal dose at 1% volume (D1%) for the spinal cord. The D(mean) of IMRT was higher than 3DCRT (p = 0.045). For V5, there was a significant difference: RA > IMRT >3DCRT (p
ISSN:1748-717X
1748-717X
DOI:10.1186/1748-717X-9-48