Inflammatory biomarkers in type 2 diabetic patients: effect of glycemic control and impact of LDL subfraction phenotype

Type 2 diabetes mellitus (T2D) is associated with higher cardiovascular risk partly related to an increase in inflammatory parameters. The aim of this study was to determine the association of inflammatory biomarkers with low-density lipoprotein (LDL) subfraction phenotype and glycemic control in su...

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Bibliographic Details
Published in:Cardiovascular diabetology 2014-02, Vol.13 (1), p.34-34
Main Authors: Vinagre, Irene, Sánchez-Quesada, José Luis, Sánchez-Hernández, Juan, Santos, David, Ordoñez-Llanos, Jordi, De Leiva, Alberto, Pérez, Antonio
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers
Biomarkers - blood
Biomedical research
Blood Glucose - metabolism
Cell culture
Cross-Sectional Studies
Cytokines
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - therapy
Female
Genotype & phenotype
Glucose
Glycemic Index - physiology
Humans
Inflammation Mediators - blood
Insulin
Insulin resistance
Lipoproteins, LDL - blood
Male
Metabolic disorders
Middle Aged
Normal distribution
Original Investigation
Phenotype
Proteins
Risk Factors
Rodents
Statins
Statistical analysis
Studies
Transforming Growth Factor beta1 - blood
Treatment Outcome
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Summary:Type 2 diabetes mellitus (T2D) is associated with higher cardiovascular risk partly related to an increase in inflammatory parameters. The aim of this study was to determine the association of inflammatory biomarkers with low-density lipoprotein (LDL) subfraction phenotype and glycemic control in subjects with T2D and poor glycemic control. A cross-sectional study was performed comparing 122 subjects with T2D (59 ± 11 years old, body mass index 30.2 ± 5.6 kg/m2) with 54 control subjects. Patients with T2D were classified according to their LDL subfraction phenotype and inflammatory biomarkers (C-reactive protein, Interleukin-6, Interleukin-8, Transforming growth factor β1, Monocyte chemotactic protein 1, Leptin, Adiponectin) were evaluated according to the degree of glycemic control, LDL phenotype and other clinical characteristics. Forty-two subjects with T2D were studied before and after 3 months of improving glycemic control by different strategies. Patients with T2D had higher C-reactive protein (CRP) and monocyte chemotactic protein-1 (MCP1) levels and lower adiponectin concentration, compared to controls. T2D subjects with body mass index ≥ 30 kg/m2 had higher CRP levels (5.2 ± 4.8 mg/l vs 3.7 ± 4.3 mg/l; p 
ISSN:1475-2840
1475-2840
DOI:10.1186/1475-2840-13-34