Epigenetics in hepatocellular carcinoma: An update and future therapy perspectives

Hepatocellular carcinoma(HCC),the predominant form of adult liver malignancies,is a global health concern.Its dismal prognosis has prompted recent significant advances in the understanding of its etiology and pathogenesis.The deregulation of epigenetic mechanisms,which maintain heritable gene expres...

Full description

Saved in:
Bibliographic Details
Published in:World journal of gastroenterology : WJG 2014-01, Vol.20 (2), p.333-345
Main Authors: Ma, Li, Chua, Mei-Sze, Andrisani, Ourania, So, Samuel
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - therapeutic use
carcinoma
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - therapy
Carcinoma, Hepatocellular - virology
Chromatin Assembly and Disassembly
DNA
DNA Methylation
Epigenesis, Genetic - drug effects
Epigenetics
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Genetic Therapy
Hepatitis B, Chronic - complications
Hepatocellular
Histones - metabolism
Humans
Liver Neoplasms - genetics
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Liver Neoplasms - therapy
Liver Neoplasms - virology
methylati
MicroRNAs - metabolism
Neoplastic Stem Cells - metabolism
Neoplastic Stem Cells - pathology
Neoplastic Stem Cells - virology
Phenotype
Prognosis
Risk Factors
RNA, Long Noncoding - metabolism
Topic Highlight
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hepatocellular carcinoma(HCC),the predominant form of adult liver malignancies,is a global health concern.Its dismal prognosis has prompted recent significant advances in the understanding of its etiology and pathogenesis.The deregulation of epigenetic mechanisms,which maintain heritable gene expression changes and chromatin organization,is implicated in the development of multiple cancers,including HCC.This review summarizes the current knowledge of epigenetic mechanisms in the pathogenesis of HCC,with an emphasis on HCC mediated by chronic hepatitis B virus infection.This review also discusses the encouraging outcomes and lessons learnt from epigenetic therapies for hematological and other solid cancers,and highlights the future potential of similar therapies in the treatment of HCC.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v20.i2.333