Outcomes and management of viral hepatitis and human immunodeficiency virus co-infection in liver transplantation

Liver transplantation for human immunodeficiency virus(HIV)positive patients with viral hepatitis co-infection is increasingly offered in many North American and European liver transplant centers.Prior studies have demonstrated acceptable post-transplant outcomes and no increased risk of HIV complic...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2014-01, Vol.20 (2), p.414-424
Main Authors: Congly, Stephen E, Doucette, Karen E, Coffin, Carla S
Format: Article
Language:English
Subjects:
Coinfection
End Stage Liver Disease - diagnosis
End Stage Liver Disease - epidemiology
End Stage Liver Disease - surgery
End Stage Liver Disease - virology
Hepatitis
Hepatitis B - diagnosis
Hepatitis B - epidemiology
Hepatitis B - surgery
Hepatitis C - diagnosis
Hepatitis C - epidemiology
Hepatitis C - surgery
HIV Infections - diagnosis
HIV Infections - epidemiology
HIV Infections - therapy
Human
Humans
immunodeficiency
Liver Transplantation - adverse effects
Patient Selection
Risk Assessment
Risk Factors
Time Factors
Topic Highlight
Treatment Outcome
virus
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Summary:Liver transplantation for human immunodeficiency virus(HIV)positive patients with viral hepatitis co-infection is increasingly offered in many North American and European liver transplant centers.Prior studies have demonstrated acceptable post-transplant outcomes and no increased risk of HIV complications in patients coinfected with hepatitis B virus(HBV).However,liver transplantation in HIV positive patients with hepatitis C virus(HCV)has poorer outcomes overall,requiring careful selection of candidates.This review aims to summarize the published literature on outcomes after transplant in HIV patients with HBV or HCV related end-stage liver disease and recommendations for management.In particular the pre-transplant factors impacting outcomes in HCV/HIV co-infected candidates and importance of multidisciplinary management will be discussed.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v20.i2.414