Correlation between biopterin levels and intimal-media thickness in type-2 diabetic hypertensive patients

Background Biopterins have a crucial role in the function of nitric oxide synthase, uncoupling of the enzyme leads to endothelial dysfunction and vascular damage, The aim of this study was to evaluate the relationship between the levels of biopterins with carotid intima-media thickness (CIMT) in hyp...

Full description

Saved in:
Bibliographic Details
Published in:Journal of diabetes and metabolic disorders 2014-01, Vol.13 (1), p.6-6, Article 6
Main Authors: Rubio-Guerra, Alberto Francisco, Vargas-Robles, Hilda, Del Valle-Mondragon, Leonardo, Maceda-Serrano, Alberto, Huerta-Ramirez, Saul, Duran-Salgado, Montserrat Berenice, Escalante-Acosta, Bruno Alfonso
Format: Article
Language:English
Subjects:
Complications and side effects
Diabetes
Diagnosis
Endocrinology
Endothelium
High performance liquid chromatography
Medicine
Medicine & Public Health
Metabolic Diseases
Physiological aspects
Research Article
Risk factors
Type 2 diabetes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Biopterins have a crucial role in the function of nitric oxide synthase, uncoupling of the enzyme leads to endothelial dysfunction and vascular damage, The aim of this study was to evaluate the relationship between the levels of biopterins with carotid intima-media thickness (CIMT) in hypertensive type-2 diabetic patients. Methods We studied 30 hypertensive type-2 diabetic patients and 30 normotensive non-diabetic age-matched subjects, in whom biopterins levels were measured by reverse phase high performance liquid chromatography with fluorescence detection. Additionally, the CIMT of both the common and internal carotid arteries was measured. The levels of biopterins and CIMT were correlated using the Pearson correlation coefficient test. Results We did not find a significantly correlation between biopterins levels and CIMT. However, we found a significantly inverse correlation between the BH4/BH2 ratio and the CIMT in patients (r = -0.54, p 
ISSN:2251-6581
2251-6581
DOI:10.1186/2251-6581-13-6