Immunohistochemical Correlation of Matrix Metalloproteinase-2 and Tissue Inhibitors of Metalloproteinase-2 in Tobacco Associated Epithelial Dysplasia

Aim. To study the immunohistochemical expression of matrix metalloproteinase and tissue inhibitors of matrix metalloproteinase-2 in different histological grades of tobacco associated epithelial dysplasia and correlate the association between these proteases. Potentially malignant oral disorders (PM...

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Bibliographic Details
Published in:Disease markers 2014-01, Vol.2014 (2014), p.1-9
Main Authors: Menon, Aparna, Shrestha, Bijayatha, Kamath, Asha, Radhakrishnan, Raghu, Bajracharya, Dipshikha
Format: Article
Language:English
Subjects:
Adult
Biomarkers, Tumor - metabolism
Causes of
Disease Progression
Dysplasia
Enzyme inhibitors
Epithelial cells
Female
Health aspects
Humans
Immunohistochemistry
Leukoplakia, Oral - enzymology
Leukoplakia, Oral - etiology
Leukoplakia, Oral - pathology
Male
Matrix Metalloproteinase 2 - metabolism
Medical research
Medicine, Experimental
Metalloproteins
Middle Aged
Mouth Mucosa - enzymology
Mouth Mucosa - pathology
Physiological aspects
Retrospective Studies
Smoking - adverse effects
Tissue Inhibitor of Metalloproteinase-2 - metabolism
Tobacco products
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Summary:Aim. To study the immunohistochemical expression of matrix metalloproteinase and tissue inhibitors of matrix metalloproteinase-2 in different histological grades of tobacco associated epithelial dysplasia and correlate the association between these proteases. Potentially malignant oral disorders (PMODs) progressing to oral cancer are related to the severity of epithelial dysplasia. Methods. A retrospective immunohistochemical study was carried out on 30 clinically and histologically proven cases of leukoplakia with dysplasia and 10 cases of normal buccal mucosa using anti-MMP-2 and anti-TIMP-2 monoclonal antibodies. Results. Mann Whitney U test, for comparing the expression of both MMP-2 and TIMP-2 in normal mucosa with dysplasia, was highly significant (P
ISSN:0278-0240
1875-8630
DOI:10.1155/2014/197813