Different Profile of Serum Leptin between Early Onset and Late Onset Preeclampsia

Aim. This study was designed to clarify the role of leptin and adiponectin in preeclampsia (PE) pathogenesis and different subtypes of preeclampsia. Method. This case control study was performed in 45 PE patients and 45 healthy controls matched for age, BMI, and ethnicity. Serum leptin and adiponect...

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Bibliographic Details
Published in:Disease markers 2014-01, Vol.2014 (2014), p.1-7
Main Authors: Farajian-Mashhadi, Farzaneh, Salimi, Saeedeh, Naghavi, Anoosh, Mokhtari, Mojgan, Shahrakipour, Mahnaz, Saravani, Mohsen, Yaghmaei, Minoo
Format: Article
Language:English
Subjects:
Adiponectin - blood
Adult
Biomarkers - blood
Case-Control Studies
Clinical Study
Development and progression
Female
Health aspects
Humans
Leptin
Leptin - blood
Pre-Eclampsia - blood
Pre-Eclampsia - pathology
Preeclampsia
Pregnancy
Severity of Illness Index
Young Adult
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Summary:Aim. This study was designed to clarify the role of leptin and adiponectin in preeclampsia (PE) pathogenesis and different subtypes of preeclampsia. Method. This case control study was performed in 45 PE patients and 45 healthy controls matched for age, BMI, and ethnicity. Serum leptin and adiponectin levels were determined by enzyme linked immunosorbent assay (ELISA). Results. Maternal serum leptin and adiponectin were significantly higher in PE women than controls. Serum leptin was elevated in early onset preeclampsia (EOPE) and late onset preeclampsia (LOPE) compared to controls. Among PE patients, serum leptin was higher in EOPE than LOPE women. However, serum adiponectin was not different between EOPE and LOPE women. The serum leptin was significantly higher in severe PE than mild PE. The serum adiponectin was significantly elevated in severe PE compared to controls. Significant positive correlation was observed between leptin and adiponectin and also between leptin and BMI in controls. Moreover significant positive correlation was observed between adiponectin and BMI in PE patients and controls. Conclusion. The present study showed that serum leptin level may play a significant role as a biomarker to differentiate early and late onset PE and also its relation to BMI and severity of disease.
ISSN:0278-0240
1875-8630
DOI:10.1155/2014/628476