SLC17: A functionally diverse family of organic anion transporters

Molecular studies have determined that the SLC17 transporters, a family of nine proteins initially implicated in phosphate transport, mediate the transport of organic anions. While their role in phosphate transport remains uncertain, it is now clear that the transport of organic anions facilitated b...

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Bibliographic Details
Published in:Molecular aspects of medicine 2013-04, Vol.34 (2-3), p.350-359
Main Author: Reimer, Richard J.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Gene Expression Regulation
Glycoproteins - metabolism
Humans
Mice
Models, Biological
Models, Molecular
Molecular Sequence Data
Multigene Family - genetics
N-Acetylneuraminic Acid - metabolism
Neurotransmitter Agents - metabolism
Neurotransmitter transporter
Organic anion transport
Organic Anion Transporters - genetics
Organic Anion Transporters - metabolism
Organic Anion Transporters - physiology
Phylogeny
Protein Conformation
Sialin
SLC17
Sodium-Phosphate Cotransporter Proteins, Type I - genetics
Symporters - genetics
Symporters - metabolism
Symporters - physiology
Transport Vesicles - metabolism
Type I phosphate transporter
Uric Acid - metabolism
Vesicular glutamate transporter
Vesicular nucleotide transporter
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Summary:Molecular studies have determined that the SLC17 transporters, a family of nine proteins initially implicated in phosphate transport, mediate the transport of organic anions. While their role in phosphate transport remains uncertain, it is now clear that the transport of organic anions facilitated by this family of proteins is involved in diverse processes ranging from the vesicular storage of the neurotransmitters, to urate metabolism, to the degradation and metabolism of glycoproteins.
ISSN:0098-2997
1872-9452
DOI:10.1016/j.mam.2012.05.004