Perioperative Organ Injury

Despite the fact that a surgical procedure may have been performed for the appropriate indication and in a technically perfect manner, patients are threatened by perioperative organ injury. For example, stroke, myocardial infarction, acute respiratory distress syndrome, acute kidney injury, or acute...

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Bibliographic Details
Published in:Anesthesiology (Philadelphia) 2013-12, Vol.119 (6), p.1474-1489
Main Authors: BARTELS, Karsten, KARHAUSEN, Jörn, CLAMBEY, Eric T, GRENZ, Almut, ELTZSCHIG, Holger K
Format: Article
Language:English
Subjects:
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Gastrointestinal Diseases - epidemiology
Gastrointestinal Diseases - pathology
Humans
Intraoperative Complications - epidemiology
Intraoperative Complications - pathology
Medical sciences
Myocardial Infarction - epidemiology
Myocardial Infarction - pathology
Perioperative Care
Perioperative Period
Postoperative Complications - epidemiology
Postoperative Complications - pathology
Respiratory Distress Syndrome, Adult - epidemiology
Respiratory Distress Syndrome, Adult - pathology
Stroke - epidemiology
Stroke - pathology
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Summary:Despite the fact that a surgical procedure may have been performed for the appropriate indication and in a technically perfect manner, patients are threatened by perioperative organ injury. For example, stroke, myocardial infarction, acute respiratory distress syndrome, acute kidney injury, or acute gut injury are among the most common causes for morbidity and mortality in surgical patients. In the current review, the authors discuss the pathogenesis of perioperative organ injury, and provide select examples for novel treatment concepts that have emerged over the past decade. Indeed, the authors are of the opinion that research to provide mechanistic insight into acute organ injury and identification of novel therapeutic approaches for the prevention or treatment of perioperative organ injury represent the most important opportunity to improve outcomes of anesthesia and surgery.
ISSN:0003-3022
1528-1175
DOI:10.1097/aln.0000000000000022