The expanded role of extracellular matrix patch in malignant and non-malignant chest wall reconstruction in thoracic surgery

OBJECTIVES The extracellular matrix (XCM Biologic Tissue Matrix) is a non-cross-linked 3D patch derived from porcine dermis. Once implanted, it is infiltrated by recipient's cells and becomes incorporated in the repair. Here, we report the first series of using this device for chest wall recons...

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Bibliographic Details
Published in:Interactive cardiovascular and thoracic surgery 2014-03, Vol.18 (3), p.335-339
Main Authors: George, Robert S., Kostopanagiotou, Kostas, Papagiannopoulos, Kostas
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Animals
Extracellular Matrix - transplantation
Female
Heterografts
Humans
Male
Middle Aged
Original
Reconstructive Surgical Procedures - adverse effects
Reconstructive Surgical Procedures - instrumentation
Swine
Thoracic Surgical Procedures - adverse effects
Thoracic Surgical Procedures - instrumentation
Thoracic Wall - pathology
Thoracic Wall - surgery
Time Factors
Tissue Scaffolds
Treatment Outcome
Wound Healing
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Summary:OBJECTIVES The extracellular matrix (XCM Biologic Tissue Matrix) is a non-cross-linked 3D patch derived from porcine dermis. Once implanted, it is infiltrated by recipient's cells and becomes incorporated in the repair. Here, we report the first series of using this device for chest wall reconstruction. METHODS The XCM Biologic Tissue Matrix was utilized to provide the restoration of chest wall defects. It was used either alone or in conjunction with the Synthes titanium system to provide additional support. The decision was made intraoperatively. RESULTS Since April 2010, 21 (12 females) patients received the device. Average age at operation was 47 ± 17 years. Eleven (52%) patients had the patch inserted alone, while the remaining 10 received it in combination with another implantable medical device. The biological tissue matrix was used to reconstruct chest wall defects in cancer involving chest wall (n = 9), chest wall deformity (n = 6), chest wall hernia (n = 5) and chest wall repair following empyema drainage (n = 1). Complications were witnessed in 3 patients receiving the combined XCM and Synthes bar mechanisms; infection (n = 2) and bar displacement and infection (n = 1). CONCLUSIONS The XCM patch can be safely used to provide the strength required for chest wall reconstruction and to replace previously infected reconstructions.
ISSN:1569-9293
1569-9285
DOI:10.1093/icvts/ivt473