ROS, Notch, and Wnt Signaling Pathways : Crosstalk between Three Major Regulators of Cardiovascular Biology

Reactive oxygen species (ROS), traditionally viewed as toxic by-products that cause damage to biomolecules, now are clearly recognized as key modulators in a variety of biological processes and pathological states. The development and regulation of the cardiovascular system require orchestrated acti...

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Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-8
Main Authors: Caliceti, Cristiana, Nigro, P., Rizzo, P., Ferrari, Roberto
Format: Article
Language:English
Subjects:
Animals
Biological control systems
Cardiovascular disease
Cardiovascular system
Cardiovascular System - metabolism
Cell adhesion & migration
Cellular signal transduction
Health aspects
Humans
Kinases
Reactive oxygen species
Reactive Oxygen Species - metabolism
Receptor Cross-Talk
Receptors, Notch - metabolism
Review
Signal Transduction
Stem cells
Wnt proteins
Wnt Signaling Pathway
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Summary:Reactive oxygen species (ROS), traditionally viewed as toxic by-products that cause damage to biomolecules, now are clearly recognized as key modulators in a variety of biological processes and pathological states. The development and regulation of the cardiovascular system require orchestrated activities; Notch and Wnt/β-catenin signaling pathways are implicated in many aspects of them, including cardiomyocytes and smooth muscle cells survival, angiogenesis, progenitor cells recruitment and differentiation, arteriovenous specification, vascular cell migration, and cardiac remodelling. Several novel findings regarding the role of ROS in Notch and Wnt/β-catenin modulation prompted us to review their emerging function in the cardiovascular system during embryogenesis and postnatally.
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/318714