Extended HLA/Complement Allele Haplotypes: Evidence for T/t-Like Complex in Man

The chromosomal distribution of alleles for HLA-A, -B, -C, and -DR and the serum complement protein alleles of factor B and C2 and C4 was studied in normal Caucasian families. Eight combinations of HLA-B, DR, BF, C2, C4A, and C4B markers were found to occur in haplotypes at frequencies significantly...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1983-01, Vol.80 (1), p.259-263
Main Authors: Awdeh, Z. L., Raum, D., Yunis, E. J., Alper, C. A.
Format: Article
Language:English
Subjects:
Alleles
Chromosomes
Complement System Proteins - genetics
Crossovers
Galactose Oxidase - genetics
Genes, MHC Class II
Genetic Linkage
Genetic loci
Genotype
Haplotypes
HLA A antigens
HLA Antigens - genetics
HLA B antigens
HLA-DR Antigens
Humans
Linkage disequilibrium
Major histocompatibility complex genes
Mutation
Sex chromosomes
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Summary:The chromosomal distribution of alleles for HLA-A, -B, -C, and -DR and the serum complement protein alleles of factor B and C2 and C4 was studied in normal Caucasian families. Eight combinations of HLA-B, DR, BF, C2, C4A, and C4B markers were found to occur in haplotypes at frequencies significantly higher than expected. In these combinations, which were defined as extended major histocompatibility complex haplotypes, HLA-A showed limited variation. A possible mechanism for the maintenance of extended haplotypes are human analogs of murine t mutants which are characterized by crossover suppression and male transmission bias. One human 6p haplotype, HLA-B8, DR3, SCO1, GLO 2, was found to be transmitted from males to 83% of their offspring. The same haplotype with GLO 1 had no transmission bias. It is suggested that this GLO 2-marked chromosome is a human analog of a murine t mutant.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.80.1.259