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A comparative cytogenetic study of miscarriages after IVF and natural conception in women aged under and over 35 years
Purpose To compare the frequency and the spectrum of karyotype abnormality in the first trimester miscarriages in women aged under and over 35 years, who conceived naturally (NC) and who conceived through in vitro fertilization (IVF). Methods Comparative analysis of cytogenetic data obtained by kary...
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| Published in: | Journal of assisted reproduction and genetics 2014-02, Vol.31 (2), p.149-155 |
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| creator | Pendina, Anna A. Efimova, Olga A. Chiryaeva, Olga G. Tikhonov, Andrei V. Petrova, Lubov’ I. Dudkina, Vera S. Sadik, Natalia A. Fedorova, Irina D. Galembo, Ilona A. Kuznetzova, Tatyana V. Gzgzyan, Alexander M. Baranov, Vladislav S. |
| description | Purpose
To compare the frequency and the spectrum of karyotype abnormality in the first trimester miscarriages in women aged under and over 35 years, who conceived naturally (NC) and who conceived through in vitro fertilization (IVF).
Methods
Comparative analysis of cytogenetic data obtained by karyotyping of miscarriages in patients who conceived naturally, and who conceived through IVF. Patients were subcategorized by their age: |
| doi_str_mv | 10.1007/s10815-013-0148-1 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3933595</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1502326394</sourcerecordid><originalsourceid>FETCH-LOGICAL-c573t-7527f4e848ccc064b55a592fb60ad45df73b4d200f57fc9ce000c9286e3bfaaf3</originalsourceid><addsrcrecordid>eNqNkt1qFTEQx4NY7Ic-gDcS8Mabtfnc7N4IpdhaKPRGvQ3Z7OSYcjY5JtlTztv0WXwys5xaqlDwImRgfvPPzOSP0FtKPlJC1GmmpKOyIZTXI7qGvkBHVCreKM7JyxoT2TVEtN0hOs75lhDSd4y_QodMcMa4EEfo7gzbOG1MMsVvAdtdiSsIULzFuczjDkeHJ5-tScmbFWRsXIGEr75fYBNGHEyZk1lXjWBhU3wM2Ad8FycIuOIjnsNY8QWN2xpw-et-Bybl1-jAmXWGNw_3Cfp28fnr-Zfm-uby6vzsurF1jtIoyZQT0InOWktaMUhpZM_c0BIzCjk6xQcxMkKcVM72FuqMtmddC3xwxjh-gj7tdTfzMMFoIZTar94kP5m009F4_Xcm-B96Fbea95zLXlaBDw8CKf6cIRe9rAPWaxMgzllTyUXHlCL8P1DCOGt5Lyr6_h_0Ns4p1E0sFJVC9a2qFN1TNsWcE7jHvinRiwP03gG6OkAvDtC01rx7OvBjxZ8vrwDbA7mmwgrSk6efVf0NlPC9qA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1501547967</pqid></control><display><type>article</type><title>A comparative cytogenetic study of miscarriages after IVF and natural conception in women aged under and over 35 years</title><source>PubMed Central Free</source><source>Springer Nature</source><creator>Pendina, Anna A. ; Efimova, Olga A. ; Chiryaeva, Olga G. ; Tikhonov, Andrei V. ; Petrova, Lubov’ I. ; Dudkina, Vera S. ; Sadik, Natalia A. ; Fedorova, Irina D. ; Galembo, Ilona A. ; Kuznetzova, Tatyana V. ; Gzgzyan, Alexander M. ; Baranov, Vladislav S.</creator><creatorcontrib>Pendina, Anna A. ; Efimova, Olga A. ; Chiryaeva, Olga G. ; Tikhonov, Andrei V. ; Petrova, Lubov’ I. ; Dudkina, Vera S. ; Sadik, Natalia A. ; Fedorova, Irina D. ; Galembo, Ilona A. ; Kuznetzova, Tatyana V. ; Gzgzyan, Alexander M. ; Baranov, Vladislav S.</creatorcontrib><description>Purpose
To compare the frequency and the spectrum of karyotype abnormality in the first trimester miscarriages in women aged under and over 35 years, who conceived naturally (NC) and who conceived through in vitro fertilization (IVF).
Methods
Comparative analysis of cytogenetic data obtained by karyotyping of miscarriages in patients who conceived naturally, and who conceived through IVF. Patients were subcategorized by their age: <35 years (NC,
n
= 173; IVF,
n
= 108) and ≥35 years (NC,
n
= 107; IVF,
n
= 111).
Results
A total of 499 miscarriage karyotypes was analyzed. The spectrum and the relative proportions of different cytogenetic categories in karyotypically abnormal miscarriages differed neither between the NC and IVF patients aged <35 years, nor between the NC and IVF patients aged ≥35 years. In the patients aged <35 years, the incidence of abnormal miscarriage karyotype was lower in the IVF group (37.04 % vs 62.43 %). In the patients aged ≥35 years, the incidence of miscarriages with cytogenetic pathology did not differ between the NC and the IVF group (75.70 % vs 58.56 %). The lowest frequency of karyotypically abnormal miscarriages (29.82 %) was detected in the young IVF-treated patients at <7 weeks of gestation.
Conclusions
IVF does not increase the risk of a pregnancy loss because of abnormal embryonic karyotype, nor does it increase the preponderance for any specific type of cytogenetic abnormality in both patients aged under and over 35 years. In young IVF-treated women early pregnancy loss is generally caused by non-cytogenetic factors. Identification of a cytogenetically normal spontaneous abortion is clinically significant and reinforces the importance of developing an appropriate diagnosis and treatment strategies for IVF patients in order to reduce the risk of euploid pregnancy loss.</description><identifier>ISSN: 1058-0468</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/s10815-013-0148-1</identifier><identifier>PMID: 24322344</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Abortion, Spontaneous - genetics ; Adult ; Age ; Chromosomes ; Cytogenetic Analysis ; Female ; Fertilization in Vitro - adverse effects ; Genetics ; Gynecology ; Human Genetics ; Humans ; In vitro fertilization ; Karyotyping ; Maternal Age ; Medical diagnosis ; Medicine ; Medicine & Public Health ; Middle Aged ; Miscarriage ; Obstetrics ; Pregnancy ; Pregnancy Trimester, First ; Reproductive Medicine ; Ultrasonic imaging ; Womens health ; Young Adult</subject><ispartof>Journal of assisted reproduction and genetics, 2014-02, Vol.31 (2), p.149-155</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c573t-7527f4e848ccc064b55a592fb60ad45df73b4d200f57fc9ce000c9286e3bfaaf3</citedby><cites>FETCH-LOGICAL-c573t-7527f4e848ccc064b55a592fb60ad45df73b4d200f57fc9ce000c9286e3bfaaf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933595/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933595/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24322344$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pendina, Anna A.</creatorcontrib><creatorcontrib>Efimova, Olga A.</creatorcontrib><creatorcontrib>Chiryaeva, Olga G.</creatorcontrib><creatorcontrib>Tikhonov, Andrei V.</creatorcontrib><creatorcontrib>Petrova, Lubov’ I.</creatorcontrib><creatorcontrib>Dudkina, Vera S.</creatorcontrib><creatorcontrib>Sadik, Natalia A.</creatorcontrib><creatorcontrib>Fedorova, Irina D.</creatorcontrib><creatorcontrib>Galembo, Ilona A.</creatorcontrib><creatorcontrib>Kuznetzova, Tatyana V.</creatorcontrib><creatorcontrib>Gzgzyan, Alexander M.</creatorcontrib><creatorcontrib>Baranov, Vladislav S.</creatorcontrib><title>A comparative cytogenetic study of miscarriages after IVF and natural conception in women aged under and over 35 years</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><addtitle>J Assist Reprod Genet</addtitle><description>Purpose
To compare the frequency and the spectrum of karyotype abnormality in the first trimester miscarriages in women aged under and over 35 years, who conceived naturally (NC) and who conceived through in vitro fertilization (IVF).
Methods
Comparative analysis of cytogenetic data obtained by karyotyping of miscarriages in patients who conceived naturally, and who conceived through IVF. Patients were subcategorized by their age: <35 years (NC,
n
= 173; IVF,
n
= 108) and ≥35 years (NC,
n
= 107; IVF,
n
= 111).
Results
A total of 499 miscarriage karyotypes was analyzed. The spectrum and the relative proportions of different cytogenetic categories in karyotypically abnormal miscarriages differed neither between the NC and IVF patients aged <35 years, nor between the NC and IVF patients aged ≥35 years. In the patients aged <35 years, the incidence of abnormal miscarriage karyotype was lower in the IVF group (37.04 % vs 62.43 %). In the patients aged ≥35 years, the incidence of miscarriages with cytogenetic pathology did not differ between the NC and the IVF group (75.70 % vs 58.56 %). The lowest frequency of karyotypically abnormal miscarriages (29.82 %) was detected in the young IVF-treated patients at <7 weeks of gestation.
Conclusions
IVF does not increase the risk of a pregnancy loss because of abnormal embryonic karyotype, nor does it increase the preponderance for any specific type of cytogenetic abnormality in both patients aged under and over 35 years. In young IVF-treated women early pregnancy loss is generally caused by non-cytogenetic factors. Identification of a cytogenetically normal spontaneous abortion is clinically significant and reinforces the importance of developing an appropriate diagnosis and treatment strategies for IVF patients in order to reduce the risk of euploid pregnancy loss.</description><subject>Abortion, Spontaneous - genetics</subject><subject>Adult</subject><subject>Age</subject><subject>Chromosomes</subject><subject>Cytogenetic Analysis</subject><subject>Female</subject><subject>Fertilization in Vitro - adverse effects</subject><subject>Genetics</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>In vitro fertilization</subject><subject>Karyotyping</subject><subject>Maternal Age</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Miscarriage</subject><subject>Obstetrics</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First</subject><subject>Reproductive Medicine</subject><subject>Ultrasonic imaging</subject><subject>Womens health</subject><subject>Young Adult</subject><issn>1058-0468</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqNkt1qFTEQx4NY7Ic-gDcS8Mabtfnc7N4IpdhaKPRGvQ3Z7OSYcjY5JtlTztv0WXwys5xaqlDwImRgfvPPzOSP0FtKPlJC1GmmpKOyIZTXI7qGvkBHVCreKM7JyxoT2TVEtN0hOs75lhDSd4y_QodMcMa4EEfo7gzbOG1MMsVvAdtdiSsIULzFuczjDkeHJ5-tScmbFWRsXIGEr75fYBNGHEyZk1lXjWBhU3wM2Ad8FycIuOIjnsNY8QWN2xpw-et-Bybl1-jAmXWGNw_3Cfp28fnr-Zfm-uby6vzsurF1jtIoyZQT0InOWktaMUhpZM_c0BIzCjk6xQcxMkKcVM72FuqMtmddC3xwxjh-gj7tdTfzMMFoIZTar94kP5m009F4_Xcm-B96Fbea95zLXlaBDw8CKf6cIRe9rAPWaxMgzllTyUXHlCL8P1DCOGt5Lyr6_h_0Ns4p1E0sFJVC9a2qFN1TNsWcE7jHvinRiwP03gG6OkAvDtC01rx7OvBjxZ8vrwDbA7mmwgrSk6efVf0NlPC9qA</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Pendina, Anna A.</creator><creator>Efimova, Olga A.</creator><creator>Chiryaeva, Olga G.</creator><creator>Tikhonov, Andrei V.</creator><creator>Petrova, Lubov’ I.</creator><creator>Dudkina, Vera S.</creator><creator>Sadik, Natalia A.</creator><creator>Fedorova, Irina D.</creator><creator>Galembo, Ilona A.</creator><creator>Kuznetzova, Tatyana V.</creator><creator>Gzgzyan, Alexander M.</creator><creator>Baranov, Vladislav S.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140201</creationdate><title>A comparative cytogenetic study of miscarriages after IVF and natural conception in women aged under and over 35 years</title><author>Pendina, Anna A. ; Efimova, Olga A. ; Chiryaeva, Olga G. ; Tikhonov, Andrei V. ; Petrova, Lubov’ I. ; Dudkina, Vera S. ; Sadik, Natalia A. ; Fedorova, Irina D. ; Galembo, Ilona A. ; Kuznetzova, Tatyana V. ; Gzgzyan, Alexander M. ; Baranov, Vladislav S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c573t-7527f4e848ccc064b55a592fb60ad45df73b4d200f57fc9ce000c9286e3bfaaf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Abortion, Spontaneous - genetics</topic><topic>Adult</topic><topic>Age</topic><topic>Chromosomes</topic><topic>Cytogenetic Analysis</topic><topic>Female</topic><topic>Fertilization in Vitro - adverse effects</topic><topic>Genetics</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>In vitro fertilization</topic><topic>Karyotyping</topic><topic>Maternal Age</topic><topic>Medical diagnosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Miscarriage</topic><topic>Obstetrics</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First</topic><topic>Reproductive Medicine</topic><topic>Ultrasonic imaging</topic><topic>Womens health</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pendina, Anna A.</creatorcontrib><creatorcontrib>Efimova, Olga A.</creatorcontrib><creatorcontrib>Chiryaeva, Olga G.</creatorcontrib><creatorcontrib>Tikhonov, Andrei V.</creatorcontrib><creatorcontrib>Petrova, Lubov’ I.</creatorcontrib><creatorcontrib>Dudkina, Vera S.</creatorcontrib><creatorcontrib>Sadik, Natalia A.</creatorcontrib><creatorcontrib>Fedorova, Irina D.</creatorcontrib><creatorcontrib>Galembo, Ilona A.</creatorcontrib><creatorcontrib>Kuznetzova, Tatyana V.</creatorcontrib><creatorcontrib>Gzgzyan, Alexander M.</creatorcontrib><creatorcontrib>Baranov, Vladislav S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pendina, Anna A.</au><au>Efimova, Olga A.</au><au>Chiryaeva, Olga G.</au><au>Tikhonov, Andrei V.</au><au>Petrova, Lubov’ I.</au><au>Dudkina, Vera S.</au><au>Sadik, Natalia A.</au><au>Fedorova, Irina D.</au><au>Galembo, Ilona A.</au><au>Kuznetzova, Tatyana V.</au><au>Gzgzyan, Alexander M.</au><au>Baranov, Vladislav S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparative cytogenetic study of miscarriages after IVF and natural conception in women aged under and over 35 years</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><stitle>J Assist Reprod Genet</stitle><addtitle>J Assist Reprod Genet</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>31</volume><issue>2</issue><spage>149</spage><epage>155</epage><pages>149-155</pages><issn>1058-0468</issn><eissn>1573-7330</eissn><abstract>Purpose
To compare the frequency and the spectrum of karyotype abnormality in the first trimester miscarriages in women aged under and over 35 years, who conceived naturally (NC) and who conceived through in vitro fertilization (IVF).
Methods
Comparative analysis of cytogenetic data obtained by karyotyping of miscarriages in patients who conceived naturally, and who conceived through IVF. Patients were subcategorized by their age: <35 years (NC,
n
= 173; IVF,
n
= 108) and ≥35 years (NC,
n
= 107; IVF,
n
= 111).
Results
A total of 499 miscarriage karyotypes was analyzed. The spectrum and the relative proportions of different cytogenetic categories in karyotypically abnormal miscarriages differed neither between the NC and IVF patients aged <35 years, nor between the NC and IVF patients aged ≥35 years. In the patients aged <35 years, the incidence of abnormal miscarriage karyotype was lower in the IVF group (37.04 % vs 62.43 %). In the patients aged ≥35 years, the incidence of miscarriages with cytogenetic pathology did not differ between the NC and the IVF group (75.70 % vs 58.56 %). The lowest frequency of karyotypically abnormal miscarriages (29.82 %) was detected in the young IVF-treated patients at <7 weeks of gestation.
Conclusions
IVF does not increase the risk of a pregnancy loss because of abnormal embryonic karyotype, nor does it increase the preponderance for any specific type of cytogenetic abnormality in both patients aged under and over 35 years. In young IVF-treated women early pregnancy loss is generally caused by non-cytogenetic factors. Identification of a cytogenetically normal spontaneous abortion is clinically significant and reinforces the importance of developing an appropriate diagnosis and treatment strategies for IVF patients in order to reduce the risk of euploid pregnancy loss.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24322344</pmid><doi>10.1007/s10815-013-0148-1</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of assisted reproduction and genetics, 2014-02, Vol.31 (2), p.149-155 |
| issn | 1058-0468 1573-7330 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3933595 |
| source | PubMed Central Free; Springer Nature |
| subjects | Abortion, Spontaneous - genetics Adult Age Chromosomes Cytogenetic Analysis Female Fertilization in Vitro - adverse effects Genetics Gynecology Human Genetics Humans In vitro fertilization Karyotyping Maternal Age Medical diagnosis Medicine Medicine & Public Health Middle Aged Miscarriage Obstetrics Pregnancy Pregnancy Trimester, First Reproductive Medicine Ultrasonic imaging Womens health Young Adult |
| title | A comparative cytogenetic study of miscarriages after IVF and natural conception in women aged under and over 35 years |
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